C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neuregulin 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000073884 Nrg1-201 ENSMUSG00000062991 10090 - 8:31818028-31918203 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000073884
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000073884 2.072±0.49 0.159±0.07 3.108±0.59 0.068±0.03 1.043±0.53 0.166±0.05 0.748±0.31 0.097±0.08 0.373±0.16 0.017±0.00 0.468±0.20 0.162±0.07 0.269±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006KM CIL_0006KM_0002 CGP 8:31818028-33385527

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IDA MAPK cascade
GO:0000902 IDA cell morphogenesis
GO:0003161 IDA cardiac conduction system development
GO:0003222 IEA ventricular trabecula myocardium morphogenesis
GO:0003712 ISO transcription cofactor activity
GO:0005176 IDA ErbB-2 class receptor binding
GO:0005615 IEA extracellular space
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 IMP nervous system development
GO:0007416 IMP synapse assembly
GO:0007422 IMP peripheral nervous system development
GO:0007507 IMP heart development
GO:0007517 IMP muscle organ development
GO:0007626 IMP locomotory behavior
GO:0008083 IEA growth factor activity
GO:0008283 IEA cell proliferation
GO:0009790 IEA embryo development
GO:0010001 IMP glial cell differentiation
GO:0010667 IEA negative regulation of cardiac muscle cell apoptotic process
GO:0016324 IEA apical plasma membrane
GO:0016477 IGI cell migration
GO:0021781 IDA glial cell fate commitment
GO:0030296 IEA protein tyrosine kinase activator activity
GO:0030307 IEA positive regulation of cell growth
GO:0030424 IDA axon
GO:0031594 IDA neuromuscular junction
GO:0038127 IEA ERBB signaling pathway
GO:0042060 IEA wound healing
GO:0042177 IDA negative regulation of protein catabolic process
GO:0043125 IEA ErbB-3 class receptor binding
GO:0043497 IEA regulation of protein heterodimerization activity
GO:0043624 IEA cellular protein complex disassembly
GO:0045202 IDA synapse
GO:0045213 IMP neurotransmitter receptor metabolic process
GO:0045595 IMP regulation of cell differentiation
GO:0045785 IEA positive regulation of cell adhesion
GO:0045860 IDA positive regulation of protein kinase activity
GO:0045892 ISO negative regulation of transcription, DNA-templated
GO:0046579 IDA positive regulation of Ras protein signal transduction
GO:0048663 IMP neuron fate commitment
GO:0051048 IEA negative regulation of secretion
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0055012 IEA ventricular cardiac muscle cell differentiation
GO:0060045 IEA positive regulation of cardiac muscle cell proliferation
GO:0060379 IEA cardiac muscle cell myoblast differentiation
GO:0060956 IEA endocardial cell differentiation
GO:0061098 IEA positive regulation of protein tyrosine kinase activity
GO:2000727 IMP positive regulation of cardiac muscle cell differentiation
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000128237 nrg2a-203 protein_coding Danio_rerio 0 211
ENSDART00000098696 nrg2a-001 protein_coding Danio_rerio 1e-25 122
ENST00000287842 NRG1-004 protein_coding Homo_sapiens 0 1773
ENST00000356819 NRG1-201 protein_coding Homo_sapiens 0 1929
ENST00000405005 NRG1-017 protein_coding Homo_sapiens 0 1596
ENST00000518084 NRG1-012 protein_coding Homo_sapiens 0 387
ENST00000518104 NRG1-009 protein_coding Homo_sapiens 0 1423
ENST00000518206 NRG1-007 protein_coding Homo_sapiens 0 196
ENST00000519240 NRG1-014 protein_coding Homo_sapiens 0 392
ENST00000519301 NRG1-008 protein_coding Homo_sapiens 0 1929
ENST00000520407 NRG1-001 protein_coding Homo_sapiens 0 291
ENST00000520502 NRG1-011 protein_coding Homo_sapiens 0 994
ENST00000521670 NRG1-006 protein_coding Homo_sapiens 0 741
ENST00000522402 NRG1-013 protein_coding Homo_sapiens 0 196
ENST00000522569 NRG1-015 retained_intron Homo_sapiens 0 448
ENST00000523041 NRG1-010 protein_coding Homo_sapiens 0 549
ENST00000523079 NRG1-003 protein_coding Homo_sapiens 0 924
ENST00000523534 NRG1-002 protein_coding Homo_sapiens 0 1929
ENST00000539990 NRG1-202 protein_coding Homo_sapiens 0 861

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