C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: protein kinase C, alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000413366 PRKCA-002 ENSG00000154229 9606 + 17:66302826-66810743 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000413366
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000413366 3.515±0.00 2.426±0.00 3.009±0.00 16.993±9.45 1.328±0.28 3.841±2.55 1.060±0.98 4.378±2.33 2.941±0.71 2.136±0.48 2.405±2.11 3.334±1.97 1.775±0.52 2.820±1.97

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003AL CIL_0003AL_0003 CGP 17:66302636-66885486

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000188 IEA inactivation of MAPK activity
GO:0001525 IEA angiogenesis
GO:0001750 IEA photoreceptor outer segment
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0002026 IEA regulation of the force of heart contraction
GO:0002062 IEA chondrocyte differentiation
GO:0002159 IMP desmosome assembly
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004697 ISS:IEA protein kinase C activity
GO:0004698 IEA calcium-dependent protein kinase C activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005783 IDA endoplasmic reticulum
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0006112 TAS energy reserve metabolic process
GO:0006468 IDA:IEA protein phosphorylation
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006874 IEA cellular calcium ion homeostasis
GO:0006937 IEA regulation of muscle contraction
GO:0007155 IEA cell adhesion
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007190 ISS activation of adenylate cyclase activity
GO:0007194 ISS negative regulation of adenylate cyclase activity
GO:0007202 TAS activation of phospholipase C activity
GO:0007268 TAS synaptic transmission
GO:0007596 TAS blood coagulation
GO:0007603 TAS phototransduction, visible light
GO:0008270 IEA zinc ion binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010467 TAS gene expression
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0010613 ISS positive regulation of cardiac muscle hypertrophy
GO:0016056 TAS rhodopsin mediated signaling pathway
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019899 IDA enzyme binding
GO:0022400 TAS regulation of rhodopsin mediated signaling pathway
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030335 IMP positive regulation of cell migration
GO:0030425 IEA dendrite
GO:0030593 IEA neutrophil chemotaxis
GO:0031666 IMP positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351 IMP negative regulation of glial cell apoptotic process
GO:0035403 IDA histone kinase activity (H3-T6 specific)
GO:0035408 IDA histone H3-T6 phosphorylation
GO:0035556 IEA intracellular signal transduction
GO:0036289 IEA peptidyl-serine autophosphorylation
GO:0043025 IEA neuronal cell body
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045177 IEA apical part of cell
GO:0045651 ISS positive regulation of macrophage differentiation
GO:0045766 IMP positive regulation of angiogenesis
GO:0045785 IMP positive regulation of cell adhesion
GO:0045931 IMP positive regulation of mitotic cell cycle
GO:0046325 IEA negative regulation of glucose import
GO:0046627 IEA negative regulation of insulin receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048471 ISS perinuclear region of cytoplasm
GO:0050729 IEA positive regulation of inflammatory response
GO:0050730 IEA regulation of peptidyl-tyrosine phosphorylation
GO:0050796 TAS regulation of insulin secretion
GO:0050930 IEA induction of positive chemotaxis
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0070555 IMP response to interleukin-1
GO:0071322 IEA cellular response to carbohydrate stimulus
GO:0090330 IDA regulation of platelet aggregation
GO:0097190 TAS apoptotic signaling pathway
GO:0097193 IEA intrinsic apoptotic signaling pathway
GO:2000707 ISS positive regulation of dense core granule biogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000059595 Prkca-001 protein_coding Mus_musculus 0 3496
ENSMUST00000100302 Prkca-004 protein_coding Mus_musculus 0 1535
ENSMUST00000064989 Prkcb-001 protein_coding Mus_musculus 0 989
ENSMUST00000143692 Prkcb-002 nonsense_mediated_decay Mus_musculus 0 989
ENSMUST00000064921 Prkcb-003 protein_coding Mus_musculus 0 987
ENSMUST00000134910 Prkca-003 processed_transcript Mus_musculus 0 689
ENSMUST00000134725 Prkca-002 processed_transcript Mus_musculus 0 433
ENSDART00000137211 prkcba-002 protein_coding Danio_rerio 0 291
ENSDART00000006211 prkcba-001 protein_coding Danio_rerio 0 291
ENSDART00000142610 prkcg-001 protein_coding Danio_rerio 0 248
ENSMUST00000133383 Apoh-002 protein_coding Mus_musculus 0.00001 58

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