C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000479770 TIRAP-008 ENSG00000150455 9606 + 11:126290856-126298845 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastHeartKidneyENST00000479770
Transcript ID Breast Heart Kidney
ENST00000479770 1.151±0.00 0.303±0.00 1.400±0.47

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007W7 CIL_0007W7_0001 VISTA 11:125757160-126360423

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0005080 IPI protein kinase C binding
GO:0005515 IPI:IEA protein binding
GO:0005546 ISS phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006954 IEA inflammatory response
GO:0007165 IEA signal transduction
GO:0007166 ISS cell surface receptor signaling pathway
GO:0030099 ISS myeloid cell differentiation
GO:0030139 ISS endocytic vesicle
GO:0030674 NAS protein binding, bridging
GO:0030890 ISS positive regulation of B cell proliferation
GO:0032496 IDA response to lipopolysaccharide
GO:0032587 ISS ruffle membrane
GO:0032648 ISS regulation of interferon-beta production
GO:0032735 ISS positive regulation of interleukin-12 production
GO:0032738 IDA positive regulation of interleukin-15 production
GO:0032757 IMP positive regulation of interleukin-8 production
GO:0032760 IMP positive regulation of tumor necrosis factor production
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034137 IMP positive regulation of toll-like receptor 2 signaling pathway
GO:0034141 ISS positive regulation of toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034145 IMP positive regulation of toll-like receptor 4 signaling pathway
GO:0035662 IPI Toll-like receptor 4 binding
GO:0035663 IPI Toll-like receptor 2 binding
GO:0035665 IDA TIRAP-dependent toll-like receptor 4 signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042803 ISS protein homodimerization activity
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044130 ISS negative regulation of growth of symbiont in host
GO:0045087 TAS innate immune response
GO:0045088 IC regulation of innate immune response
GO:0045410 IMP positive regulation of interleukin-6 biosynthetic process
GO:0046330 IMP positive regulation of JNK cascade
GO:0046982 IDA protein heterodimerization activity
GO:0050830 ISS defense response to Gram-positive bacterium
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0070935 IDA 3'-UTR-mediated mRNA stabilization
GO:0071221 ISS cellular response to bacterial lipopeptide
GO:0071223 ISS cellular response to lipoteichoic acid
GO:0090023 ISS positive regulation of neutrophil chemotaxis
GO:0090073 IDA positive regulation of protein homodimerization activity
GO:2000340 ISS positive regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000343 ISS positive regulation of chemokine (C-X-C motif) ligand 2 production

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000176685 Tirap-003 protein_coding Mus_musculus 0 431
ENSMUST00000177129 Tirap-002 protein_coding Mus_musculus 0 431
ENSMUST00000176531 Tirap-004 protein_coding Mus_musculus 0 431
ENSMUST00000175765 Tirap-001 protein_coding Mus_musculus 0 431
ENSMUST00000176021 Tirap-005 protein_coding Mus_musculus 0 361
ENSMUST00000135399 Usp16-007 retained_intron Mus_musculus 0.00004 55

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