C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: DNA-damage-inducible transcript 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000547303 DDIT3-006 ENSG00000175197 9606 - 12:57516588-57520492 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeColonKidneyLungENST00000547303
Transcript ID Adipose Colon Kidney Lung
ENST00000547303 20.057±0.00 14.882±0.00 3.103±0.00 37.090±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003677 IDA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003714 TAS transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0006355 IMP:IEA regulation of transcription, DNA-templated
GO:0006974 TAS cellular response to DNA damage stimulus
GO:0006986 IDA response to unfolded protein
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007050 IEA cell cycle arrest
GO:0008134 IPI transcription factor binding
GO:0016055 IEA Wnt signaling pathway
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0032757 IMP positive regulation of interleukin-8 production
GO:0034976 IDA response to endoplasmic reticulum stress
GO:0042789 IDA mRNA transcription from RNA polymerase II promoter
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0043620 TAS regulation of DNA-templated transcription in response to stress
GO:0044267 TAS cellular protein metabolic process
GO:0044324 ISS regulation of transcription involved in anterior/posterior axis specification
GO:0045454 IDA cell redox homeostasis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0070059 IMP intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090090 ISS negative regulation of canonical Wnt signaling pathway
GO:2000016 IDA negative regulation of determination of dorsal identity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000026475 Ddit3-001 protein_coding Mus_musculus 0 754
ENSMUST00000139091 Ddit3-002 protein_coding Mus_musculus 0 562
ENSMUST00000134686 Ddit3-003 retained_intron Mus_musculus 5e-40 169

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