C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: furin (paired basic amino acid cleaving enzyme)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000610579 FURIN-201 ENSG00000140564 9606 + 15:90871539-90883458 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000610579
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000610579 64.357±0.00 25.127±0.00 2.622±0.00 8.842±6.38 21.572±19.52 13.583±10.37 10.202±8.75 26.273±0.26 57.141±54.54 29.464±25.29 14.875±12.15 16.248±8.85 53.506±12.93 8.922±4.51

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008AY CIL_0008AY_0001 VISTA 15:90522657-91123707
CIL_00077N CIL_00077N_0002 CGP 15:90868592-90895776

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0002020 IPI protease binding
GO:0004175 IDA endopeptidase activity
GO:0004252 IEA:IDA serine-type endopeptidase activity
GO:0004867 IDA serine-type endopeptidase inhibitor activity
GO:0005796 TAS Golgi lumen
GO:0005802 IDA trans-Golgi network
GO:0005886 TAS plasma membrane
GO:0006465 IDA signal peptide processing
GO:0006508 IEA:TAS proteolysis
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007219 TAS Notch signaling pathway
GO:0008233 IDA peptidase activity
GO:0008283 IMP cell proliferation
GO:0009986 IDA cell surface
GO:0010951 IDA negative regulation of endopeptidase activity
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016032 TAS viral process
GO:0016485 IDA protein processing
GO:0016486 IDA peptide hormone processing
GO:0017187 TAS peptidyl-glutamic acid carboxylation
GO:0019058 IEP viral life cycle
GO:0019068 TAS virion assembly
GO:0019082 TAS viral protein processing
GO:0022617 TAS extracellular matrix disassembly
GO:0030140 IDA trans-Golgi network transport vesicle
GO:0030198 TAS extracellular matrix organization
GO:0030574 TAS collagen catabolic process
GO:0032455 TAS nerve growth factor processing
GO:0032804 IDA negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032902 IDA nerve growth factor production
GO:0032911 IMP negative regulation of transforming growth factor beta1 production
GO:0032940 IDA secretion by cell
GO:0042176 IMP regulation of protein catabolic process
GO:0042277 IDA peptide binding
GO:0043043 IDA peptide biosynthetic process
GO:0043687 TAS post-translational protein modification
GO:0044267 TAS cellular protein metabolic process
GO:0045121 IDA membrane raft
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048406 IDA nerve growth factor binding
GO:0051044 IC positive regulation of membrane protein ectodomain proteolysis
GO:0052548 IDA regulation of endopeptidase activity
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000122232 Furin-001 protein_coding Mus_musculus 0 3535
ENSMUST00000107362 Furin-201 protein_coding Mus_musculus 0 3463
ENSMUST00000120753 Furin-002 protein_coding Mus_musculus 0 3463
ENSMUST00000146771 Furin-004 retained_intron Mus_musculus 0 1384
ENSMUST00000135306 Furin-005 protein_coding Mus_musculus 0 372
ENSMUST00000153446 Furin-003 retained_intron Mus_musculus 0 370
ENSMUST00000147150 Furin-006 protein_coding Mus_musculus 0 331
ENSDART00000131198 PCSK6-201 protein_coding Danio_rerio 0 241

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