C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lysine (K)-specific demethylase 1A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000004487 KDM1A 9606 + 1:23019448-23083689 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000356634 KDM1A-001 23019448-23083689 protein_coding
  ENST00000400181 KDM1A-002 23019493-23083688 protein_coding
  ENST00000465864 KDM1A-005 23072124-23079595 protein_coding
  ENST00000481879 KDM1A-003 23050425-23055418 retained_intron
  ENST00000494920 KDM1A-004 23077234-23083354 protein_coding
  ENST00000602503 KDM1A-006 23080873-23083682 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000356634ENST00000400181ENST00000494920ENST00000602503
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000356634 9.404±0.00 9.507±0.00 4.152±2.36 6.028±0.16 7.214±3.03 1.481±0.89 2.148±1.01 5.025±0.51 5.185±1.81 4.811±0.00 13.187±5.57 12.084±4.27 30.616±19.57
ENST00000400181 5.518±0.00 N/A 5.136±1.21 N/A 3.641±0.00 N/A N/A N/A 2.179±0.05 N/A 9.178±0.00 5.395±0.00 13.558±0.00
ENST00000494920 N/A 13.046±0.00 N/A N/A 9.042±0.00 N/A 8.679±0.00 6.769±0.00 10.325±0.00 14.594±0.00 24.727±9.73 17.496±0.00 45.525±8.23
ENST00000602503 N/A 2.663±0.00 1.602±0.00 1.593±0.00 N/A N/A 1.368±0.12 1.730±0.00 2.030±0.43 N/A 3.239±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0001085 IEA RNA polymerase II transcription factor binding
GO:0001701 IEA in utero embryonic development
GO:0002039 IPI p53 binding
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 ISS transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0006482 IMP protein demethylation
GO:0007596 TAS blood coagulation
GO:0008134 IDA transcription factor binding
GO:0008283 IEA cell proliferation
GO:0010725 IEA regulation of primitive erythrocyte differentiation
GO:0016491 IDA:IEA oxidoreductase activity
GO:0019899 IPI enzyme binding
GO:0021983 IEA pituitary gland development
GO:0030374 IMP ligand-dependent nuclear receptor transcription coactivator activity
GO:0030851 IEA granulocyte differentiation
GO:0032091 IMP negative regulation of protein binding
GO:0032451 IMP demethylase activity
GO:0032452 IDA histone demethylase activity
GO:0032453 IDA histone demethylase activity (H3-K4 specific)
GO:0032454 IDA histone demethylase activity (H3-K9 specific)
GO:0033169 IDA histone H3-K9 demethylation
GO:0034648 IDA histone demethylase activity (H3-dimethyl-K4 specific)
GO:0034720 IDA:IEA histone H3-K4 demethylation
GO:0043392 IC negative regulation of DNA binding
GO:0043426 IDA MRF binding
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518 IMP negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045648 IEA positive regulation of erythrocyte differentiation
GO:0045654 IEA positive regulation of megakaryocyte differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046886 IEA positive regulation of hormone biosynthetic process
GO:0050660 IDA:IEA flavin adenine dinucleotide binding
GO:0050681 IDA androgen receptor binding
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051572 IEA negative regulation of histone H3-K4 methylation
GO:0051573 IEA negative regulation of histone H3-K9 methylation
GO:0055001 ISS muscle cell development
GO:0055114 IEA oxidation-reduction process
GO:1902166 IMP negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000179 IEA positive regulation of neural precursor cell proliferation
GO:2000648 IEA positive regulation of stem cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060679 kdm1a lysine (K)-specific demethylase 1a protein_coding Danio_rerio
ENSMUSG00000036940 Kdm1a lysine (K)-specific demethylase 1A protein_coding Mus_musculus

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