C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: lysine (K)-specific demethylase 1A
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000400181 KDM1A-002 ENSG00000004487 9606 + 1:23019493-23083688 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainColonLungOvaryPlacentaTestisENST00000400181
Transcript ID Adipose Brain Colon Lung Ovary Placenta Testis
ENST00000400181 5.518±0.00 5.136±1.21 3.641±0.00 2.179±0.05 9.178±0.00 5.395±0.00 13.558±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0001085 IEA RNA polymerase II transcription factor binding
GO:0001701 IEA in utero embryonic development
GO:0002039 IPI p53 binding
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 ISS transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0006482 IMP protein demethylation
GO:0007596 TAS blood coagulation
GO:0008134 IDA transcription factor binding
GO:0008283 IEA cell proliferation
GO:0010725 IEA regulation of primitive erythrocyte differentiation
GO:0016491 IDA:IEA oxidoreductase activity
GO:0019899 IPI enzyme binding
GO:0021983 IEA pituitary gland development
GO:0030374 IMP ligand-dependent nuclear receptor transcription coactivator activity
GO:0030851 IEA granulocyte differentiation
GO:0032091 IMP negative regulation of protein binding
GO:0032451 IMP demethylase activity
GO:0032452 IDA histone demethylase activity
GO:0032453 IDA histone demethylase activity (H3-K4 specific)
GO:0032454 IDA histone demethylase activity (H3-K9 specific)
GO:0033169 IDA histone H3-K9 demethylation
GO:0034648 IDA histone demethylase activity (H3-dimethyl-K4 specific)
GO:0034720 IDA:IEA histone H3-K4 demethylation
GO:0043392 IC negative regulation of DNA binding
GO:0043426 IDA MRF binding
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518 IMP negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045648 IEA positive regulation of erythrocyte differentiation
GO:0045654 IEA positive regulation of megakaryocyte differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046886 IEA positive regulation of hormone biosynthetic process
GO:0050660 IDA:IEA flavin adenine dinucleotide binding
GO:0050681 IDA androgen receptor binding
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051572 IEA negative regulation of histone H3-K4 methylation
GO:0051573 IEA negative regulation of histone H3-K9 methylation
GO:0055001 ISS muscle cell development
GO:0055114 IEA oxidation-reduction process
GO:1902166 IMP negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000179 IEA positive regulation of neural precursor cell proliferation
GO:2000648 IEA positive regulation of stem cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000105847 Kdm1a-002 protein_coding Mus_musculus 0 3496
ENSMUST00000116273 Kdm1a-001 protein_coding Mus_musculus 0 2765
ENSMUST00000046846 Kdm1a-007 protein_coding Mus_musculus 0 1657
ENSMUST00000170979 Kdm1a-009 protein_coding Mus_musculus 0 1301
ENSMUST00000147886 Kdm1a-004 retained_intron Mus_musculus 0 922
ENSMUST00000155354 Kdm1a-003 protein_coding Mus_musculus 0 780
ENSMUST00000125111 Kdm1a-005 retained_intron Mus_musculus 0 616
ENSMUST00000171424 Kdm1a-008 retained_intron Mus_musculus 0 405
ENSMUST00000139690 Kdm1a-006 retained_intron Mus_musculus 0 377

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