C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: lysine (K)-specific demethylase 1A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000036940 Kdm1a 10090 - 4:136550540-136602723 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000046846 Kdm1a-007 136550848-136602308 protein_coding
  ENSMUST00000105847 Kdm1a-002 136550544-136602687 protein_coding
  ENSMUST00000116273 Kdm1a-001 136550540-136602723 protein_coding
  ENSMUST00000125111 Kdm1a-005 136553121-136555324 retained_intron
  ENSMUST00000139690 Kdm1a-006 136551873-136553172 retained_intron
  ENSMUST00000147886 Kdm1a-004 136555207-136561501 retained_intron
  ENSMUST00000155354 Kdm1a-003 136555235-136568607 protein_coding
  ENSMUST00000170979 Kdm1a-009 136558532-136577158 protein_coding
  ENSMUST00000171424 Kdm1a-008 136550877-136552542 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000046846ENSMUST00000105847ENSMUST00000116273ENSMUST00000125111ENSMUST00000170979
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000046846 N/A N/A N/A 23.233±0.00 N/A N/A 1.654±0.00 N/A 1.626±0.01 N/A N/A N/A 8.514±0.55 7.593±0.30
ENSMUST00000105847 7.364±2.30 1.624±0.00 9.168±0.04 16.894±7.66 6.841±2.86 2.250±0.00 5.093±1.15 4.534±1.39 4.926±3.15 6.025±1.94 4.973±0.87 11.385±6.90 18.107±4.11 21.034±2.49
ENSMUST00000116273 5.342±1.86 4.235±0.96 6.859±0.90 18.549±12.23 4.845±2.50 7.546±1.64 2.813±0.55 2.534±1.01 4.390±3.03 5.738±2.63 2.269±0.66 9.186±3.57 10.425±4.92 N/A
ENSMUST00000125111 N/A N/A N/A N/A 6.212±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000170979 N/A N/A N/A 10.366±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000208 CIL_000208_0002 CGP 4:136469761-136602723

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0001085 IPI RNA polymerase II transcription factor binding
GO:0001701 IMP in utero embryonic development
GO:0002039 IEA p53 binding
GO:0003677 IEA DNA binding
GO:0003682 ISS chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005667 IDA transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0006482 IEA protein demethylation
GO:0008134 IPI transcription factor binding
GO:0008283 IMP cell proliferation
GO:0010725 IMP regulation of primitive erythrocyte differentiation
GO:0016491 IEA oxidoreductase activity
GO:0019899 IPI enzyme binding
GO:0021983 IMP pituitary gland development
GO:0030374 ISS ligand-dependent nuclear receptor transcription coactivator activity
GO:0030851 IMP granulocyte differentiation
GO:0032091 IEA negative regulation of protein binding
GO:0032451 IEA demethylase activity
GO:0032452 ISS histone demethylase activity
GO:0032453 ISS histone demethylase activity (H3-K4 specific)
GO:0032454 ISS histone demethylase activity (H3-K9 specific)
GO:0033169 ISS histone H3-K9 demethylation
GO:0034401 IC regulation of transcription by chromatin organization
GO:0034648 ISS histone demethylase activity (H3-dimethyl-K4 specific)
GO:0034720 IEA histone H3-K4 demethylation
GO:0043426 IPI MRF binding
GO:0043433 ISS negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518 IEA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045648 IMP positive regulation of erythrocyte differentiation
GO:0045654 IMP positive regulation of megakaryocyte differentiation
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046886 IMP positive regulation of hormone biosynthetic process
GO:0050660 IEA flavin adenine dinucleotide binding
GO:0050681 ISS androgen receptor binding
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051572 IMP negative regulation of histone H3-K4 methylation
GO:0051573 IMP negative regulation of histone H3-K9 methylation
GO:0055001 IMP muscle cell development
GO:0055114 IEA oxidation-reduction process
GO:1902166 IEA negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000179 IMP positive regulation of neural precursor cell proliferation
GO:2000648 IMP positive regulation of stem cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060679 kdm1a lysine (K)-specific demethylase 1a protein_coding Danio_rerio
ENSG00000004487 KDM1A lysine (K)-specific demethylase 1A protein_coding Homo_sapiens

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