C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000005844 ITGAL 9606 + 16:30472658-30523185 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000356798 ITGAL-001 30472658-30523185 protein_coding
  ENST00000358164 ITGAL-002 30472729-30522968 protein_coding
  ENST00000433423 ITGAL-004 30472751-30521779 protein_coding
  ENST00000562020 ITGAL-021 30504872-30506772 retained_intron
  ENST00000562652 ITGAL-010 30472719-30474607 nonsense_mediated_decay
  ENST00000562857 ITGAL-003 30472746-30483964 nonsense_mediated_decay
  ENST00000563615 ITGAL-020 30499172-30510395 nonsense_mediated_decay
  ENST00000564118 ITGAL-007 30472750-30483964 protein_coding
  ENST00000564632 ITGAL-023 30519756-30522243 retained_intron
  ENST00000564935 ITGAL-017 30489000-30494856 retained_intron
  ENST00000565348 ITGAL-012 30472746-30483964 processed_transcript
  ENST00000565864 ITGAL-011 30472746-30479190 nonsense_mediated_decay
  ENST00000566149 ITGAL-015 30483891-30489304 retained_intron
  ENST00000566267 ITGAL-022 30509359-30517070 processed_transcript
  ENST00000568012 ITGAL-016 30488883-30496201 processed_transcript
  ENST00000568926 ITGAL-009 30472745-30510414 nonsense_mediated_decay
  ENST00000568987 ITGAL-018 30496432-30504219 retained_intron
  ENST00000569570 ITGAL-005 30472722-30475402 processed_transcript
  ENST00000569725 ITGAL-008 30474001-30479174 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000356798ENST00000358164ENST00000433423ENST00000564118ENST00000564632ENST00000564935ENST00000565348ENST00000566149ENST00000566267ENST00000568012ENST00000568987
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000356798 0.158±0.00 8.538±0.00 N/A 0.065±0.03 0.530±0.00 0.094±0.05 1.063±0.00 0.211±0.00 8.388±6.29 N/A 0.361±0.00 0.889±0.09 N/A
ENST00000358164 0.750±0.00 5.006±0.00 N/A N/A 0.812±0.00 0.038±0.00 N/A 0.698±0.00 N/A 0.087±0.00 0.580±0.00 1.301±0.65 0.398±0.00
ENST00000433423 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.540±0.00 N/A 0.769±0.00
ENST00000564118 N/A N/A N/A N/A N/A N/A N/A 1.521±0.00 N/A N/A N/A N/A N/A
ENST00000564632 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.790±0.00 4.705±0.00 1.055±0.00
ENST00000564935 N/A N/A N/A 0.488±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000565348 N/A N/A 0.144±0.00 1.012±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000566149 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.670±0.00
ENST00000566267 N/A N/A 0.161±0.00 0.442±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000568012 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.259±0.00 N/A N/A N/A
ENST00000568987 N/A N/A 0.665±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000U7 CIL_0000U7_0001 CGP 16:30472658-30526821

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 IEA immunological synapse
GO:0002291 IMP T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006928 TAS cellular component movement
GO:0006954 NAS inflammatory response
GO:0007155 NAS cell adhesion
GO:0007157 IMP heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 IMP leukocyte cell-cell adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007165 NAS signal transduction
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007596 TAS blood coagulation
GO:0008305 NAS integrin complex
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0022407 IEA regulation of cell-cell adhesion
GO:0022409 IEA positive regulation of cell-cell adhesion
GO:0030198 TAS extracellular matrix organization
GO:0030369 IMP ICAM-3 receptor activity
GO:0032403 IEA protein complex binding
GO:0034687 IDA integrin alphaL-beta2 complex
GO:0042102 IEA positive regulation of T cell proliferation
GO:0043113 IMP receptor clustering
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0050776 TAS regulation of immune response
GO:0050798 IEA activated T cell proliferation
GO:0050839 IPI cell adhesion molecule binding
GO:0050850 IEA positive regulation of calcium-mediated signaling
GO:0050900 TAS leukocyte migration
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044670 ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) protein_coding Danio_rerio
ENSMUSG00000030830 Itgal integrin alpha L protein_coding Mus_musculus

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