C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000356798 ITGAL-001 ENSG00000005844 9606 + 16:30472658-30523185 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastHeartKidneyLiverLungOvaryPlacentaENST00000356798
Transcript ID Adipose Adrenal Brain Breast Heart Kidney Liver Lung Ovary Placenta
ENST00000356798 0.158±0.00 8.538±0.00 0.065±0.03 0.530±0.00 0.094±0.05 1.063±0.00 0.211±0.00 8.388±6.29 0.361±0.00 0.889±0.09

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000U7 CIL_0000U7_0001 CGP 16:30472658-30526821

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001772 IEA immunological synapse
GO:0002291 IMP T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006928 TAS cellular component movement
GO:0006954 NAS inflammatory response
GO:0007155 NAS cell adhesion
GO:0007157 IMP heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 IMP leukocyte cell-cell adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007165 NAS signal transduction
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007229 IEA integrin-mediated signaling pathway
GO:0007596 TAS blood coagulation
GO:0008305 NAS integrin complex
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0016020 IDA membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0022407 IEA regulation of cell-cell adhesion
GO:0022409 IEA positive regulation of cell-cell adhesion
GO:0030198 TAS extracellular matrix organization
GO:0030369 IMP ICAM-3 receptor activity
GO:0032403 IEA protein complex binding
GO:0034687 IDA integrin alphaL-beta2 complex
GO:0042102 IEA positive regulation of T cell proliferation
GO:0043113 IMP receptor clustering
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0050776 TAS regulation of immune response
GO:0050798 IEA activated T cell proliferation
GO:0050839 IPI cell adhesion molecule binding
GO:0050850 IEA positive regulation of calcium-mediated signaling
GO:0050900 TAS leukocyte migration
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000106306 Itgal-001 protein_coding Mus_musculus 0 2241
ENSMUST00000170971 Itgal-201 protein_coding Mus_musculus 0 2237
ENSMUST00000117762 Itgal-002 protein_coding Mus_musculus 0 2237
ENSMUST00000120857 Itgal-003 protein_coding Mus_musculus 0 2134
ENSMUST00000118405 Itgal-004 protein_coding Mus_musculus 0 1498

Loading