C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin alpha L
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030830 Itgal 10090 + 7:127296260-127335137 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000106306 Itgal-001 127296291-127335137 protein_coding
  ENSMUST00000117762 Itgal-002 127296260-127335137 protein_coding
  ENSMUST00000118405 Itgal-004 127309518-127335137 protein_coding
  ENSMUST00000120857 Itgal-003 127296315-127331291 protein_coding
  ENSMUST00000170971 Itgal-201 127296410-127333728 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000106306ENSMUST00000117762ENSMUST00000118405ENSMUST00000120857ENSMUST00000170971
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000106306 1.279±0.54 0.679±0.22 0.591±0.16 N/A 9.816±3.41 1.438±0.35 0.850±0.42 1.131±0.38 2.005±0.80 8.675±0.93 0.037±0.00 1.032±0.50 0.219±0.06 0.133±0.04
ENSMUST00000117762 1.897±1.14 N/A 0.382±0.00 0.067±0.01 6.231±1.58 1.090±0.02 0.567±0.15 1.794±0.00 0.769±0.15 3.360±0.00 0.706±0.00 0.970±0.42 0.149±0.06 N/A
ENSMUST00000118405 1.505±0.29 0.433±0.29 0.518±0.23 0.116±0.01 10.611±1.17 1.031±0.10 0.441±0.13 0.956±0.36 2.092±1.12 7.907±0.60 0.071±0.03 0.869±0.43 0.167±0.04 0.235±0.07
ENSMUST00000120857 N/A N/A N/A 0.024±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.105±0.00 0.074±0.01
ENSMUST00000170971 N/A 0.165±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.032±0.00 0.187±0.00 0.297±0.16 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000U7 CIL_0000U7_0002 CGP 7:127296260-127345314

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 IDA immunological synapse
GO:0002291 IEA T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0005515 IEA protein binding
GO:0005911 IDA cell-cell junction
GO:0007157 IEA heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007160 IEA cell-matrix adhesion
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007229 IEA integrin-mediated signaling pathway
GO:0008305 IEA integrin complex
GO:0009897 IDA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0016020 IEA membrane
GO:0016337 IEA single organismal cell-cell adhesion
GO:0022407 IDA regulation of cell-cell adhesion
GO:0022409 IMP positive regulation of cell-cell adhesion
GO:0030369 IEA ICAM-3 receptor activity
GO:0032403 IEA protein complex binding
GO:0034687 IEA integrin alphaL-beta2 complex
GO:0042102 IMP positive regulation of T cell proliferation
GO:0043113 IEA receptor clustering
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0050798 IMP activated T cell proliferation
GO:0050839 IEA cell adhesion molecule binding
GO:0050850 IDA positive regulation of calcium-mediated signaling
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044670 ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) protein_coding Danio_rerio
ENSG00000005844 ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) protein_coding Homo_sapiens

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