C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Bruton agammaglobulinemia tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000010671 BTK 9606 - X:101349447-101390796 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308731 BTK-006 101349450-101386195 protein_coding
  ENST00000372880 BTK-201 101349447-101386224 protein_coding
  ENST00000464006 BTK-003 101362191-101362815 processed_transcript
  ENST00000464567 BTK-004 101374306-101386148 processed_transcript
  ENST00000470069 BTK-008 101353043-101353984 processed_transcript
  ENST00000470329 BTK-002 101356511-101358361 retained_intron
  ENST00000478995 BTK-001 101355585-101356804 retained_intron
  ENST00000488970 BTK-005 101353319-101354221 processed_transcript
  ENST00000618050 BTK-202 101349447-101375284 protein_coding
  ENST00000621635 BTK-203 101349447-101390796 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000308731ENST00000618050ENST00000621635
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000308731 0.332±0.00 N/A 0.351±0.00 N/A 0.263±0.14 0.488±0.00 0.838±0.00 0.519±0.00 1.387±0.77 0.653±0.29 1.771±0.76 N/A
ENST00000618050 0.638±0.00 6.223±0.00 0.349±0.00 1.356±0.00 0.389±0.00 0.380±0.00 0.278±0.00 N/A 2.170±0.64 0.581±0.44 1.026±0.61 1.043±0.38
ENST00000621635 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.133±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000DX CIL_0000DX_0001 CGP X:101345661-101390796
CIL_0000DV CIL_0000DV_0001 CGP X:101349447-101396154

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002250 TAS adaptive immune response
GO:0002553 IEA histamine secretion by mast cell
GO:0002721 TAS regulation of B cell cytokine production
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002902 TAS regulation of B cell apoptotic process
GO:0004672 IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004715 TAS non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 TAS:IEA ATP binding
GO:0005547 IDA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 TAS nucleus
GO:0005737 TAS cytoplasm
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006468 TAS:IEA protein phosphorylation
GO:0007249 IEA I-kappaB kinase/NF-kappaB signaling
GO:0007498 TAS mesoderm development
GO:0010033 IEA response to organic substance
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019722 TAS calcium-mediated signaling
GO:0031410 IEA cytoplasmic vesicle
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034614 IEA cellular response to reactive oxygen species
GO:0035556 TAS:IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042113 TAS B cell activation
GO:0042629 IEA mast cell granule
GO:0042802 IPI identical protein binding
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045087 TAS innate immune response
GO:0045121 IDA membrane raft
GO:0045579 TAS positive regulation of B cell differentiation
GO:0046777 IEA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0048469 IEA cell maturation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050853 TAS B cell receptor signaling pathway
GO:0051092 TAS positive regulation of NF-kappaB transcription factor activity
GO:0071226 IEA cellular response to molecule of fungal origin
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004433 btk Bruton agammaglobulinemia tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000031264 Btk Bruton agammaglobulinemia tyrosine kinase protein_coding Mus_musculus

Loading