C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Bruton agammaglobulinemia tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031264 Btk 10090 - X:134542336-134583570 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033617 Btk-001 134542336-134583140 protein_coding
  ENSMUST00000113213 Btk-002 134542370-134583128 protein_coding
  ENSMUST00000128333 Btk-003 134573209-134583570 processed_transcript
  ENSMUST00000132664 Btk-005 134549221-134583140 retained_intron
  ENSMUST00000150245 Btk-004 134568905-134582473 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033617ENSMUST00000113213ENSMUST00000128333ENSMUST00000132664
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033617 0.666±0.09 0.180±0.10 1.072±0.26 0.100±0.04 2.249±1.08 0.334±0.11 0.267±0.08 0.227±0.11 3.503±3.69 1.066±0.47 0.170±0.18 0.466±0.40 0.392±0.13 0.126±0.02
ENSMUST00000113213 N/A N/A N/A N/A N/A N/A N/A N/A 0.092±0.00 N/A 0.113±0.00 0.166±0.01 N/A N/A
ENSMUST00000128333 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.791±0.38 N/A
ENSMUST00000132664 N/A 0.347±0.00 N/A 0.048±0.00 1.552±0.00 0.282±0.14 N/A N/A 0.114±0.00 N/A 0.108±0.10 0.096±0.06 0.177±0.04 0.095±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000DX CIL_0000DX_0002 CGP X:134537256-134583570
CIL_0000DV CIL_0000DV_0002 CGP X:134542336-134588062

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002553 IEA histamine secretion by mast cell
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005547 IEA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007249 IMP I-kappaB kinase/NF-kappaB signaling
GO:0010033 IEA response to organic substance
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0031410 IDA cytoplasmic vesicle
GO:0034614 IEA cellular response to reactive oxygen species
GO:0042629 IEA mast cell granule
GO:0042802 IEA identical protein binding
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0045087 IEA innate immune response
GO:0045121 IEA membrane raft
GO:0046777 IEA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0048469 IMP cell maturation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0071226 IEA cellular response to molecule of fungal origin

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004433 btk Bruton agammaglobulinemia tyrosine kinase protein_coding Danio_rerio
ENSG00000010671 BTK Bruton agammaglobulinemia tyrosine kinase protein_coding Homo_sapiens

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