C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WW domain containing transcription regulator 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000018408 WWTR1 9606 - 3:149517235-149736714 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360632 WWTR1-004 149520245-149658101 protein_coding
  ENST00000460517 WWTR1-007 149657244-149658041 protein_coding
  ENST00000465804 WWTR1-001 149517235-149703273 protein_coding
  ENST00000467467 WWTR1-003 149520610-149658025 protein_coding
  ENST00000471586 WWTR1-012 149520699-149541060 nonsense_mediated_decay
  ENST00000472417 WWTR1-010 149520841-149576252 protein_coding
  ENST00000474080 WWTR1-002 149701605-149736714 processed_transcript
  ENST00000475579 WWTR1-006 149656978-149670909 protein_coding
  ENST00000479238 WWTR1-009 149572864-149657435 protein_coding
  ENST00000485244 WWTR1-011 149525805-149542439 retained_intron
  ENST00000485352 WWTR1-008 149656891-149657767 protein_coding
  ENST00000494754 WWTR1-013 149520722-149540266 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderMuscleOvaryPlacentaTestisENST00000360632ENST00000465804ENST00000474080
Transcript ID Bladder Muscle Ovary Placenta Testis
ENST00000360632 N/A 0.466±0.00 N/A N/A N/A
ENST00000465804 1.696±0.00 N/A 13.824±0.00 2.403±0.00 0.750±0.00
ENST00000474080 N/A 0.325±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002R1 CIL_0002R1_0001 CGP 3:149473974-149736714
CIL_0002R8 CIL_0002R8_0001 CGP 3:149517235-149752499

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001649 IEA osteoblast differentiation
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0003713 NAS transcription coactivator activity
GO:0003714 IEA transcription corepressor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 TAS transcription, DNA-templated
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006469 IMP negative regulation of protein kinase activity
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0008284 IDA positive regulation of cell proliferation
GO:0010467 TAS gene expression
GO:0010718 IDA positive regulation of epithelial to mesenchymal transition
GO:0016567 IEA protein ubiquitination
GO:0017145 IDA stem cell division
GO:0031146 IEA SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032835 IEA glomerulus development
GO:0035264 IEA multicellular organism growth
GO:0035329 IDA hippo signaling
GO:0035414 IMP negative regulation of catenin import into nucleus
GO:0042803 IEA protein homodimerization activity
GO:0045599 IEA negative regulation of fat cell differentiation
GO:0045944 TAS positive regulation of transcription from RNA polymerase II promoter
GO:0048762 IEA mesenchymal cell differentiation
GO:0060271 IEA cilium morphogenesis
GO:0060390 IDA regulation of SMAD protein import into nucleus
GO:0060828 IEA regulation of canonical Wnt signaling pathway
GO:0060993 IEA kidney morphogenesis
GO:0072307 IEA regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000067719 wwtr1 WW domain containing transcription regulator 1 protein_coding Danio_rerio
ENSMUSG00000027803 Wwtr1 WW domain containing transcription regulator 1 protein_coding Mus_musculus

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