C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear receptor subfamily 1, group H, member 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000025434 NR1H3 9606 + 11:47248300-47269032 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000395397 NR1H3-031 47248916-47268812 protein_coding
  ENST00000405576 NR1H3-003 47248916-47268843 protein_coding
  ENST00000405853 NR1H3-006 47257998-47268843 protein_coding
  ENST00000407404 NR1H3-002 47248956-47268781 protein_coding
  ENST00000412937 NR1H3-012 47257658-47261280 protein_coding
  ENST00000419652 NR1H3-014 47257710-47259823 nonsense_mediated_decay
  ENST00000420369 NR1H3-019 47257996-47261345 nonsense_mediated_decay
  ENST00000436029 NR1H3-016 47257971-47261377 protein_coding
  ENST00000436778 NR1H3-007 47248927-47261347 protein_coding
  ENST00000437276 NR1H3-017 47257963-47259952 protein_coding
  ENST00000441012 NR1H3-030 47257962-47268784 protein_coding
  ENST00000444396 NR1H3-010 47257604-47261322 protein_coding
  ENST00000449369 NR1H3-013 47257697-47261356 protein_coding
  ENST00000457932 NR1H3-011 47257623-47259979 protein_coding
  ENST00000461778 NR1H3-015 47257917-47261280 processed_transcript
  ENST00000462051 NR1H3-024 47267945-47268844 retained_intron
  ENST00000467728 NR1H3-001 47257979-47268845 protein_coding
  ENST00000473222 NR1H3-022 47259464-47260625 processed_transcript
  ENST00000476086 NR1H3-038 47258001-47260678 processed_transcript
  ENST00000481020 NR1H3-005 47248924-47268831 retained_intron
  ENST00000481889 NR1H3-023 47248924-47268831 protein_coding
  ENST00000483882 NR1H3-021 47259587-47260587 retained_intron
  ENST00000486991 NR1H3-009 47257708-47258506 retained_intron
  ENST00000487913 NR1H3-008 47248927-47262019 retained_intron
  ENST00000494018 NR1H3-025 47268141-47268844 retained_intron
  ENST00000495866 NR1H3-026 47248300-47260506 processed_transcript
  ENST00000498548 NR1H3-018 47258880-47259969 retained_intron
  ENST00000525441 NR1H3-039 47257970-47261421 processed_transcript
  ENST00000527464 NR1H3-028 47248300-47261974 processed_transcript
  ENST00000527949 NR1H3-032 47260397-47268817 protein_coding
  ENST00000529540 NR1H3-029 47248311-47268838 processed_transcript
  ENST00000530310 NR1H3-035 47258106-47260616 processed_transcript
  ENST00000531660 NR1H3-037 47248927-47268008 protein_coding
  ENST00000532630 NR1H3-036 47248927-47268816 processed_transcript
  ENST00000616973 NR1H3-201 47248300-47269032 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000395397ENST00000405576ENST00000405853ENST00000412937ENST00000441012ENST00000467728ENST00000494018ENST00000527464ENST00000529540ENST00000616973
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000395397 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.550±0.00 N/A 13.928±1.80
ENST00000405576 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.707±0.00
ENST00000405853 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.093±0.00 N/A N/A N/A
ENST00000412937 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.777±0.00 N/A N/A N/A
ENST00000441012 N/A N/A 2.141±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 7.327±0.00 28.009±0.00 N/A
ENST00000467728 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.914±0.00 N/A N/A N/A N/A
ENST00000494018 N/A N/A N/A 6.103±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 18.147±0.00
ENST00000527464 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.947±0.00 N/A N/A
ENST00000529540 38.224±0.00 37.640±0.00 N/A N/A 41.982±0.00 14.606±0.00 3.389±0.00 18.475±0.00 24.202±0.00 N/A 2.802±0.00 N/A N/A 20.003±0.00
ENST00000616973 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.495±0.00 7.715±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 TAS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0003713 TAS transcription coactivator activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0008270 IEA zinc ion binding
GO:0010467 TAS gene expression
GO:0010745 IC negative regulation of macrophage derived foam cell differentiation
GO:0010867 IMP positive regulation of triglyceride biosynthetic process
GO:0010870 IDA positive regulation of receptor biosynthetic process
GO:0010875 IDA positive regulation of cholesterol efflux
GO:0010887 IMP negative regulation of cholesterol storage
GO:0015485 TAS cholesterol binding
GO:0030522 IEA intracellular receptor signaling pathway
GO:0032270 IMP positive regulation of cellular protein metabolic process
GO:0032369 IMP negative regulation of lipid transport
GO:0032376 IDA positive regulation of cholesterol transport
GO:0032570 IDA response to progesterone
GO:0032810 IDA sterol response element binding
GO:0034145 IDA positive regulation of toll-like receptor 4 signaling pathway
GO:0042632 ISS cholesterol homeostasis
GO:0042752 TAS regulation of circadian rhythm
GO:0043031 ISS negative regulation of macrophage activation
GO:0043277 IMP apoptotic cell clearance
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044255 IEA cellular lipid metabolic process
GO:0045723 IMP positive regulation of fatty acid biosynthetic process
GO:0045861 IEA negative regulation of proteolysis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048550 IMP negative regulation of pinocytosis
GO:0050728 ISS negative regulation of inflammatory response
GO:0051006 IMP positive regulation of lipoprotein lipase activity
GO:0055088 ISS lipid homeostasis
GO:0055092 ISS sterol homeostasis
GO:0060336 NAS negative regulation of interferon-gamma-mediated signaling pathway
GO:0070328 ISS triglyceride homeostasis
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0090188 ISS negative regulation of pancreatic juice secretion
GO:0090341 ISS negative regulation of secretion of lysosomal enzymes
GO:2000188 ISS regulation of cholesterol homeostasis
GO:2000189 IDA positive regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043170 nr1h3 nuclear receptor subfamily 1, group H, member 3 protein_coding Danio_rerio
ENSMUSG00000002108 Nr1h3 nuclear receptor subfamily 1, group H, member 3 protein_coding Mus_musculus

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