C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: nuclear receptor subfamily 1, group H, member 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000467728 NR1H3-001 ENSG00000025434 9606 + 11:47257979-47268845 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; LungENST00000467728
Transcript ID Lung
ENST00000467728 0.914±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0003677 TAS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0003713 TAS transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 TAS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0008270 IEA zinc ion binding
GO:0010467 TAS gene expression
GO:0010745 IC negative regulation of macrophage derived foam cell differentiation
GO:0010867 IMP positive regulation of triglyceride biosynthetic process
GO:0010870 IDA positive regulation of receptor biosynthetic process
GO:0010875 IDA positive regulation of cholesterol efflux
GO:0010887 IMP negative regulation of cholesterol storage
GO:0015485 TAS cholesterol binding
GO:0032270 IMP positive regulation of cellular protein metabolic process
GO:0032369 IMP negative regulation of lipid transport
GO:0032376 IDA positive regulation of cholesterol transport
GO:0032570 IDA response to progesterone
GO:0032810 IDA sterol response element binding
GO:0034145 IDA positive regulation of toll-like receptor 4 signaling pathway
GO:0042632 ISS cholesterol homeostasis
GO:0042752 TAS regulation of circadian rhythm
GO:0043031 ISS negative regulation of macrophage activation
GO:0043277 IMP apoptotic cell clearance
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045723 IMP positive regulation of fatty acid biosynthetic process
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048550 IMP negative regulation of pinocytosis
GO:0050728 ISS negative regulation of inflammatory response
GO:0051006 IMP positive regulation of lipoprotein lipase activity
GO:0055088 ISS lipid homeostasis
GO:0055092 ISS sterol homeostasis
GO:0060336 NAS negative regulation of interferon-gamma-mediated signaling pathway
GO:0070328 ISS triglyceride homeostasis
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0090188 ISS negative regulation of pancreatic juice secretion
GO:0090341 ISS negative regulation of secretion of lysosomal enzymes
GO:2000188 ISS regulation of cholesterol homeostasis
GO:2000189 IDA positive regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000111356 Nr1h3-007 protein_coding Mus_musculus 0 1718
ENSMUST00000111354 Nr1h3-002 protein_coding Mus_musculus 0 1714
ENSMUST00000002177 Nr1h3-001 protein_coding Mus_musculus 0 1714
ENSMUST00000130031 Nr1h3-005 retained_intron Mus_musculus 0 944
ENSMUST00000111355 Nr1h3-003 protein_coding Mus_musculus 0 808
ENSMUST00000150654 Nr1h3-004 retained_intron Mus_musculus 0 808
ENSDART00000130731 nr1h3-203 protein_coding Danio_rerio 0 512
ENSDART00000123268 nr1h3-202 protein_coding Danio_rerio 0 512
ENSMUST00000136234 Nr1h3-006 processed_transcript Mus_musculus 0 248

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