C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear receptor subfamily 1, group H, member 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000002108 Nr1h3 10090 - 2:91184061-91202834 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000002177 Nr1h3-001 91184061-91195116 protein_coding
  ENSMUST00000111354 Nr1h3-002 91184092-91195151 protein_coding
  ENSMUST00000111355 Nr1h3-003 91184092-91194885 protein_coding
  ENSMUST00000111356 Nr1h3-007 91184061-91195035 protein_coding
  ENSMUST00000130031 Nr1h3-005 91184206-91192744 retained_intron
  ENSMUST00000133261 Nr1h3-008 91190185-91190935 retained_intron
  ENSMUST00000136234 Nr1h3-006 91192031-91202834 processed_transcript
  ENSMUST00000150654 Nr1h3-004 91184061-91195025 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000002177ENSMUST00000111354ENSMUST00000111355ENSMUST00000111356ENSMUST00000130031ENSMUST00000150654
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000002177 24.032±8.43 8.396±2.42 4.706±0.02 0.645±0.08 11.151±2.31 3.035±0.00 3.287±0.17 10.460±1.30 18.064±11.24 17.184±1.56 2.987±1.45 3.236±0.78 4.021±3.56 1.627±0.50
ENSMUST00000111354 36.118±20.15 15.279±4.61 2.531±0.32 0.241±0.06 39.104±9.63 13.326±4.53 5.894±1.06 28.504±3.43 33.679±26.12 19.748±7.00 3.518±0.79 7.750±3.46 3.784±2.35 6.610±2.99
ENSMUST00000111355 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.077±0.00 0.955±0.00 1.953±0.00
ENSMUST00000111356 N/A N/A 1.185±0.00 0.269±0.00 N/A 1.585±0.00 1.414±0.00 N/A 2.807±0.76 N/A 1.157±0.06 1.559±0.17 0.529±0.00 N/A
ENSMUST00000130031 N/A 4.853±1.10 1.551±0.00 0.354±0.15 7.967±0.00 2.071±0.00 1.793±0.10 N/A N/A 7.372±0.01 1.102±0.00 1.762±0.59 1.018±0.00 N/A
ENSMUST00000150654 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.536±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00017Z CIL_00017Z_0002 CGP 2:91137360-91202834

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006633 TAS fatty acid biosynthetic process
GO:0008270 IEA zinc ion binding
GO:0010875 IDA positive regulation of cholesterol efflux
GO:0010887 IGI negative regulation of cholesterol storage
GO:0030522 IDA intracellular receptor signaling pathway
GO:0042632 IGI cholesterol homeostasis
GO:0043031 IDA negative regulation of macrophage activation
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044255 IDA cellular lipid metabolic process
GO:0045861 IMP negative regulation of proteolysis
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050728 IDA negative regulation of inflammatory response
GO:0055088 IGI lipid homeostasis
GO:0055092 IMP sterol homeostasis
GO:0070328 IMP triglyceride homeostasis
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0090188 IMP negative regulation of pancreatic juice secretion
GO:0090341 IMP negative regulation of secretion of lysosomal enzymes
GO:2000188 IMP regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043170 nr1h3 nuclear receptor subfamily 1, group H, member 3 protein_coding Danio_rerio
ENSG00000025434 NR1H3 nuclear receptor subfamily 1, group H, member 3 protein_coding Homo_sapiens

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