C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: trio Rho guanine nucleotide exchange factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000038382 TRIO 9606 + 5:14143702-14532128 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344135 TRIO-009 14488448-14510203 protein_coding
  ENST00000344204 TRIO-001 14143702-14510204 protein_coding
  ENST00000502490 TRIO-019 14388613-14397341 retained_intron
  ENST00000502816 TRIO-012 14143702-14290887 retained_intron
  ENST00000503399 TRIO-016 14492370-14496986 retained_intron
  ENST00000504606 TRIO-013 14290977-14297513 retained_intron
  ENST00000505971 TRIO-011 14143702-14287104 retained_intron
  ENST00000506611 TRIO-005 14474012-14477333 retained_intron
  ENST00000507714 TRIO-014 14419814-14420800 processed_transcript
  ENST00000508283 TRIO-021 14498516-14504674 retained_intron
  ENST00000508343 TRIO-017 14498139-14499181 retained_intron
  ENST00000508717 TRIO-022 14498516-14508333 retained_intron
  ENST00000509354 TRIO-020 14399024-14420186 retained_intron
  ENST00000509967 TRIO-008 14183798-14399400 protein_coding
  ENST00000510281 TRIO-007 14482417-14487789 retained_intron
  ENST00000510757 TRIO-023 14387343-14387950 retained_intron
  ENST00000511019 TRIO-006 14479321-14481796 retained_intron
  ENST00000512070 TRIO-010 14143837-14508676 nonsense_mediated_decay
  ENST00000512303 TRIO-018 14406214-14419904 retained_intron
  ENST00000512979 TRIO-015 14418783-14420021 processed_transcript
  ENST00000513206 TRIO-002 14290977-14532128 protein_coding
  ENST00000515144 TRIO-003 14293041-14489165 retained_intron
  ENST00000515710 TRIO-004 14440819-14466451 processed_transcript
  ENST00000620511 TRIO-201 14465589-14510201 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000344135ENST00000344204ENST00000509967ENST00000512070ENST00000513206ENST00000515144ENST00000620511
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000344135 N/A N/A N/A 4.779±0.00 3.570±0.00 N/A N/A N/A 0.939±0.00 1.598±0.00 N/A 4.091±0.00 N/A 4.754±0.00
ENST00000344204 2.251±0.00 2.662±0.00 N/A 1.424±0.00 2.618±0.63 1.613±0.00 3.574±0.00 1.108±0.00 1.282±0.02 2.769±1.08 0.376±0.00 2.743±1.06 2.519±1.84 N/A
ENST00000509967 N/A N/A 0.911±0.00 N/A N/A N/A N/A N/A 1.952±0.00 7.393±0.00 N/A 3.825±0.00 N/A N/A
ENST00000512070 3.610±0.00 1.925±0.00 1.162±0.00 4.338±0.79 3.114±1.50 3.563±0.17 1.091±0.03 1.094±0.66 1.993±0.00 2.847±0.00 1.547±0.28 4.882±0.62 2.203±0.09 2.233±1.22
ENST00000513206 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.101±0.00
ENST00000515144 N/A N/A N/A 3.655±0.00 N/A N/A 0.991±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000620511 N/A N/A N/A N/A N/A N/A N/A 2.565±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005085 TAS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0007185 TAS transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0019899 IEA enzyme binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 TAS positive regulation of GTPase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000370 triob trio Rho guanine nucleotide exchange factor b protein_coding Danio_rerio
ENSDARG00000019426 trioa trio Rho guanine nucleotide exchange factor a protein_coding Danio_rerio
ENSMUSG00000022263 Trio triple functional domain (PTPRF interacting) protein_coding Mus_musculus

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