C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: catenin (cadherin-associated protein), alpha 1, 102kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000044115 CTNNA1 9606 + 5:138610967-138935034 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302763 CTNNA1-001 138753423-138935034 protein_coding
  ENST00000517533 CTNNA1-027 138875433-138917819 protein_coding
  ENST00000517534 CTNNA1-020 138827627-138887732 retained_intron
  ENST00000517656 CTNNA1-029 138875440-138887574 protein_coding
  ENST00000517904 CTNNA1-042 138886229-138904792 retained_intron
  ENST00000517980 CTNNA1-015 138610967-138810089 protein_coding
  ENST00000518263 CTNNA1-033 138875435-138881138 processed_transcript
  ENST00000518381 CTNNA1-038 138874038-138904387 protein_coding
  ENST00000518585 CTNNA1-018 138790926-138824692 processed_transcript
  ENST00000518825 CTNNA1-006 138781923-138934831 protein_coding
  ENST00000518910 CTNNA1-014 138753431-138824734 protein_coding
  ENST00000518919 CTNNA1-045 138811959-138824683 retained_intron
  ENST00000519113 CTNNA1-010 138753661-138810155 protein_coding
  ENST00000519116 CTNNA1-028 138875464-138904437 protein_coding
  ENST00000519309 CTNNA1-012 138753446-138824629 nonsense_mediated_decay
  ENST00000519489 CTNNA1-041 138924589-138925491 retained_intron
  ENST00000519634 CTNNA1-031 138875433-138887608 protein_coding
  ENST00000519768 CTNNA1-035 138875437-138887517 protein_coding
  ENST00000520158 CTNNA1-011 138754369-138824588 protein_coding
  ENST00000520260 CTNNA1-024 138875266-138887552 protein_coding
  ENST00000520339 CTNNA1-008 138753418-138783374 protein_coding
  ENST00000520400 CTNNA1-021 138870275-138917818 processed_transcript
  ENST00000520520 CTNNA1-040 138930638-138934162 protein_coding
  ENST00000520522 CTNNA1-037 138880195-138887608 protein_coding
  ENST00000520865 CTNNA1-026 138875432-138887566 protein_coding
  ENST00000521368 CTNNA1-044 138904399-138930509 nonsense_mediated_decay
  ENST00000521387 CTNNA1-039 138924530-138931074 retained_intron
  ENST00000521640 CTNNA1-034 138875443-138887578 protein_coding
  ENST00000521683 CTNNA1-036 138875440-138904375 protein_coding
  ENST00000521724 CTNNA1-003 138753421-138934213 nonsense_mediated_decay
  ENST00000521941 CTNNA1-009 138753445-138762098 processed_transcript
  ENST00000522013 CTNNA1-023 138875230-138917779 protein_coding
  ENST00000522052 CTNNA1-043 138875488-138917854 nonsense_mediated_decay
  ENST00000522227 CTNNA1-017 138610978-138810105 protein_coding
  ENST00000522730 CTNNA1-046 138824768-138828232 retained_intron
  ENST00000522792 CTNNA1-005 138931901-138935033 retained_intron
  ENST00000523275 CTNNA1-019 138824677-138887521 nonsense_mediated_decay
  ENST00000523298 CTNNA1-030 138875400-138917793 protein_coding
  ENST00000523685 CTNNA1-025 138875433-138917847 protein_coding
  ENST00000523912 CTNNA1-007 138753097-138810204 protein_coding
  ENST00000524127 CTNNA1-016 138663837-138783353 protein_coding
  ENST00000524292 CTNNA1-032 138875399-138881106 processed_transcript
  ENST00000540387 CTNNA1-201 138875653-138935028 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302763ENST00000518825ENST00000520158ENST00000521368ENST00000521387ENST00000521724ENST00000540387
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302763 14.793±0.00 14.392±0.00 7.228±0.00 11.789±0.00 15.939±6.62 19.581±0.00 25.268±17.21 15.272±8.27 9.068±4.34 33.297±20.19 11.959±2.24 35.567±29.69 32.320±11.97 8.430±0.00
ENST00000518825 38.548±0.00 27.078±0.00 N/A 35.525±0.00 37.547±0.00 46.143±0.00 30.866±0.00 41.654±0.00 9.616±0.00 51.423±0.00 20.288±0.00 N/A N/A 26.590±0.00
ENST00000520158 N/A N/A 17.463±0.00 N/A 40.537±0.00 N/A 19.033±0.00 N/A N/A N/A N/A 29.992±0.00 N/A N/A
ENST00000521368 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 91.163±0.00 125.179±0.00 35.031±0.00
ENST00000521387 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 41.134±0.00 N/A 19.877±0.00
ENST00000521724 25.933±0.00 N/A 6.498±0.00 N/A 20.391±5.88 16.677±0.00 7.426±0.00 13.240±7.82 5.322±0.00 23.767±14.44 13.161±0.00 10.069±3.24 27.706±0.00 12.375±0.00
ENST00000540387 N/A 17.041±0.00 N/A N/A N/A N/A N/A 23.923±0.00 6.757±0.00 N/A N/A 15.380±0.00 N/A 9.401±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005DA CIL_0005DA_0001 CGP 5:138554882-138935034
CIL_00062R CIL_00062R_0002 CGP 5:138610967-138935034

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001541 IEA ovarian follicle development
GO:0001669 IEA acrosomal vesicle
GO:0005198 IEA structural molecule activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005912 IEA adherens junction
GO:0005913 IEA cell-cell adherens junction
GO:0005915 IEA zonula adherens
GO:0005925 IDA focal adhesion
GO:0007155 NAS:IEA cell adhesion
GO:0007163 IEA establishment or maintenance of cell polarity
GO:0007406 IEA negative regulation of neuroblast proliferation
GO:0007568 IEA aging
GO:0008013 IPI beta-catenin binding
GO:0008584 IEA male gonad development
GO:0014070 IEA response to organic cyclic compound
GO:0014704 IEA intercalated disc
GO:0015629 IEA actin cytoskeleton
GO:0016264 IEA gap junction assembly
GO:0016342 IDA catenin complex
GO:0017166 IPI vinculin binding
GO:0030027 IEA lamellipodium
GO:0031103 IEA axon regeneration
GO:0034329 TAS cell junction assembly
GO:0034332 TAS adherens junction organization
GO:0034613 IEA cellular protein localization
GO:0042127 IEA regulation of cell proliferation
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042692 TAS muscle cell differentiation
GO:0043066 IEA negative regulation of apoptotic process
GO:0043297 NAS apical junction assembly
GO:0043627 IEA response to estrogen
GO:0044822 IDA poly(A) RNA binding
GO:0045216 TAS cell-cell junction organization
GO:0045295 IPI gamma-catenin binding
GO:0045296 IEA:IPI cadherin binding
GO:0045880 IEA positive regulation of smoothened signaling pathway
GO:0051015 IEA actin filament binding
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051291 IEA protein heterooligomerization
GO:0071681 IDA cellular response to indole-3-methanol
GO:0090136 IEA epithelial cell-cell adhesion
GO:2000146 IEA negative regulation of cell motility
GO:2001045 IEA negative regulation of integrin-mediated signaling pathway
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 IEA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077846 ctnna1 catenin (cadherin-associated protein), alpha 1 protein_coding Danio_rerio
ENSMUSG00000037815 Ctnna1 catenin (cadherin associated protein), alpha 1 protein_coding Mus_musculus

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