C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000050327 ARHGEF5 9606 + 7:144355288-144380632 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000056217 ARHGEF5-001 144355340-144380632 protein_coding
  ENST00000471847 ARHGEF5-005 144366133-144380056 protein_coding
  ENST00000474817 ARHGEF5-002 144364909-144380631 protein_coding
  ENST00000498580 ARHGEF5-004 144355288-144367339 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000056217ENST00000471847ENST00000474817
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000056217 N/A N/A 0.613±0.00 0.017±0.00 0.366±0.00 0.898±0.00 0.121±0.00 0.208±0.00 N/A 0.449±0.00 0.023±0.00 0.519±0.00 0.724±0.11 0.188±0.00
ENST00000471847 N/A N/A 1.056±0.00 N/A 1.726±0.00 N/A N/A 0.564±0.00 1.257±0.00 1.849±0.00 0.072±0.00 4.370±0.00 3.514±0.00 1.381±0.00
ENST00000474817 1.726±0.00 1.104±0.00 0.504±0.00 0.404±0.00 3.085±0.00 1.371±0.45 0.116±0.00 6.665±0.00 1.793±0.00 2.344±0.00 N/A 4.369±3.26 2.493±0.68 1.843±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00074V CIL_00074V_0001 CGP 7:144318125-144380632
CIL_00074U CIL_00074U_0001 CGP 7:144355288-144410227

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002408 IEA myeloid dendritic cell chemotaxis
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005525 TAS GTP binding
GO:0030036 IEA actin cytoskeleton organization
GO:0032319 IDA regulation of Rho GTPase activity
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0071803 IEA positive regulation of podosome assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076383 ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 protein_coding Danio_rerio
ENSMUSG00000033542 Arhgef5 Rho guanine nucleotide exchange factor (GEF) 5 protein_coding Mus_musculus

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