C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: potassium voltage-gated channel, subfamily H (eag-related), member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000055118 KCNH2 9606 - 7:150944961-150978315 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262186 KCNH2-001 150944961-150978315 protein_coding
  ENST00000330883 KCNH2-004 150944961-150955906 protein_coding
  ENST00000430723 KCNH2-201 150949899-150978100 protein_coding
  ENST00000461280 KCNH2-008 150949423-150955810 retained_intron
  ENST00000473610 KCNH2-005 150949416-150955828 retained_intron
  ENST00000532957 KCNH2-002 150949415-150978136 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262186ENST00000330883ENST00000430723ENST00000461280ENST00000532957
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262186 N/A 0.546±0.00 N/A 1.672±0.98 N/A 1.168±1.07 7.506±5.88 0.320±0.00 N/A 0.698±0.00 N/A 3.549±0.00 N/A 5.928±0.00
ENST00000330883 0.110±0.00 N/A N/A 0.906±0.00 0.148±0.00 5.046±4.66 N/A N/A N/A 0.347±0.00 N/A 5.120±4.45 0.806±0.23 7.935±3.50
ENST00000430723 N/A N/A 0.066±0.00 N/A N/A N/A N/A N/A 0.085±0.00 N/A 0.011±0.00 0.679±0.00 0.539±0.00 N/A
ENST00000461280 0.321±0.00 2.885±0.00 N/A 2.682±0.00 0.192±0.00 5.398±4.95 N/A 0.490±0.00 0.787±0.00 1.263±0.00 N/A 2.283±2.45 0.355±0.00 5.387±1.69
ENST00000532957 N/A N/A N/A 1.491±0.00 N/A N/A 24.607±0.00 N/A N/A 0.127±0.00 N/A 1.017±0.82 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008T1 CIL_0008T1_0001 VISTA 7:150668461-151272977
CIL_0004OG CIL_0004OG_0001 CGP 7:150944961-151014588

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000155 IEA phosphorelay sensor kinase activity
GO:0000160 IEA phosphorelay signal transduction system
GO:0003064 TAS regulation of heart rate by hormone
GO:0004871 IEA signal transducer activity
GO:0005216 IEA ion channel activity
GO:0005242 IDA inward rectifier potassium channel activity
GO:0005249 IDA voltage-gated potassium channel activity
GO:0005251 IDA delayed rectifier potassium channel activity
GO:0005515 IPI:IEA protein binding
GO:0005635 IEA nuclear envelope
GO:0005737 IEA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006811 IEA ion transport
GO:0007165 IEA signal transduction
GO:0007268 TAS synaptic transmission
GO:0008076 IDA voltage-gated potassium channel complex
GO:0009986 IDA cell surface
GO:0016020 IEA membrane
GO:0023014 IEA signal transduction by phosphorylation
GO:0031625 IPI ubiquitin protein ligase binding
GO:0035690 IDA cellular response to drug
GO:0042391 IDA regulation of membrane potential
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0055075 IDA potassium ion homeostasis
GO:0055085 IEA transmembrane transport
GO:0060048 IMP cardiac muscle contraction
GO:0060306 IDA regulation of membrane repolarization
GO:0060307 IMP regulation of ventricular cardiac muscle cell membrane repolarization
GO:0071435 IDA potassium ion export
GO:0071805 IDA potassium ion transmembrane transport
GO:0086005 IMP ventricular cardiac muscle cell action potential
GO:0086010 IDA membrane depolarization during action potential
GO:0086011 IDA membrane repolarization during action potential
GO:0086013 IMP membrane repolarization during cardiac muscle cell action potential
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:1901379 IDA regulation of potassium ion transmembrane transport
GO:1901380 IDA negative regulation of potassium ion transmembrane transport
GO:1901381 IDA positive regulation of potassium ion transmembrane transport
GO:1902282 IMP voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1902303 IDA negative regulation of potassium ion export

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029881 kcnh2a potassium voltage-gated channel, subfamily H (eag-related), member 2a protein_coding Danio_rerio
ENSDARG00000060053 KCNH7 (4 of 6) potassium voltage-gated channel, subfamily H (eag-related), member 2 protein_coding Danio_rerio
ENSMUSG00000038319 Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 protein_coding Mus_musculus

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