C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ATP-binding cassette, sub-family A (ABC1), member 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000064687 ABCA7 9606 + 19:1040101-1065572 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263094 ABCA7-201 1040103-1065569 protein_coding
  ENST00000433129 ABCA7-001 1041246-1065572 protein_coding
  ENST00000435683 ABCA7-002 1042625-1065572 protein_coding
  ENST00000524383 ABCA7-017 1064659-1065328 processed_transcript
  ENST00000524850 ABCA7-006 1040120-1042391 protein_coding
  ENST00000525073 ABCA7-013 1056934-1065569 protein_coding
  ENST00000525238 ABCA7-004 1040118-1042465 retained_intron
  ENST00000525939 ABCA7-015 1062261-1063945 retained_intron
  ENST00000526885 ABCA7-003 1040103-1042744 retained_intron
  ENST00000527496 ABCA7-008 1041205-1042104 retained_intron
  ENST00000529442 ABCA7-009 1056928-1058740 nonsense_mediated_decay
  ENST00000530092 ABCA7-011 1054076-1055939 nonsense_mediated_decay
  ENST00000530703 ABCA7-005 1040116-1041682 retained_intron
  ENST00000531467 ABCA7-007 1041202-1042176 protein_coding
  ENST00000531478 ABCA7-016 1064052-1065572 retained_intron
  ENST00000532194 ABCA7-014 1057040-1059263 retained_intron
  ENST00000533574 ABCA7-010 1045532-1047554 processed_transcript
  ENST00000611490 ABCA7-018 1040101-1041553 protein_coding
  ENST00000612569 ABCA7-012 1062179-1065458 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263094ENST00000433129ENST00000435683ENST00000524850ENST00000525073ENST00000526885ENST00000529442ENST00000531478ENST00000532194
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263094 0.918±0.00 1.406±0.00 N/A N/A 0.957±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000433129 N/A N/A 0.093±0.00 1.098±0.00 1.567±0.00 N/A 0.435±0.41 0.960±0.00 N/A 0.851±0.49 N/A 2.224±0.00 1.394±0.03 N/A
ENST00000435683 0.660±0.00 N/A N/A 0.110±0.00 0.272±0.00 N/A N/A 0.764±0.00 0.312±0.00 1.524±0.00 N/A N/A 1.687±0.00 0.619±0.22
ENST00000524850 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.990±0.00 N/A N/A
ENST00000525073 3.145±0.00 3.028±0.00 N/A N/A 2.232±0.00 0.598±0.25 N/A 3.795±0.00 0.620±0.00 5.049±0.00 0.787±0.00 2.032±2.09 3.116±1.24 2.307±0.00
ENST00000526885 N/A N/A N/A N/A N/A N/A N/A N/A 0.299±0.00 N/A N/A N/A N/A N/A
ENST00000529442 N/A N/A 1.272±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000531478 N/A N/A N/A 4.447±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 3.606±0.00 N/A
ENST00000532194 N/A N/A N/A N/A N/A N/A 0.205±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XG CIL_0008XG_0001 VISTA 19:477571-1083531
CIL_0000I2 CIL_0000I2_0001 CGP 19:1026581-1065572
CIL_0000HU CIL_0000HU_0001 CGP 19:1040101-1086628

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001891 ISS phagocytic cup
GO:0005215 TAS transporter activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005548 IEA phospholipid transporter activity
GO:0005622 IEA intracellular
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0006200 IEA ATP catabolic process
GO:0006909 IEA phagocytosis
GO:0007613 ISS memory
GO:0009986 ISS cell surface
GO:0010875 ISS positive regulation of cholesterol efflux
GO:0016021 TAS integral component of membrane
GO:0016324 IEA apical plasma membrane
GO:0016887 IDA:IEA ATPase activity
GO:0017121 IDA phospholipid scrambling
GO:0018149 ISS peptide cross-linking
GO:0032587 ISS ruffle membrane
GO:0032780 IDA negative regulation of ATPase activity
GO:0032781 IDA positive regulation of ATPase activity
GO:0033344 IDA cholesterol efflux
GO:0033700 IDA phospholipid efflux
GO:0034188 IDA apolipoprotein A-I receptor activity
GO:0034380 IDA high-density lipoprotein particle assembly
GO:0034504 ISS protein localization to nucleus
GO:0038027 IDA apolipoprotein A-I-mediated signaling pathway
GO:0042985 ISS negative regulation of amyloid precursor protein biosynthetic process
GO:0043190 TAS ATP-binding cassette (ABC) transporter complex
GO:0050766 ISS positive regulation of phagocytosis
GO:0055085 TAS transmembrane transport
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:1900223 ISS positive regulation of beta-amyloid clearance
GO:1901076 ISS positive regulation of engulfment of apoptotic cell
GO:1902430 ISS negative regulation of beta-amyloid formation
GO:1902995 ISS positive regulation of phospholipid efflux

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074221 ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 protein_coding Danio_rerio
ENSMUSG00000035722 Abca7 ATP-binding cassette, sub-family A (ABC1), member 7 protein_coding Mus_musculus

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