C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: malic enzyme 1, NADP(+)-dependent, cytosolic
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000065833 ME1 9606 - 6:83210389-83431071 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000369705 ME1-001 83210389-83431071 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000369705
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000369705 7.570±0.00 3.555±0.00 0.426±0.00 5.998±1.02 18.765±14.46 3.704±0.17 3.851±2.41 2.248±0.88 4.376±1.02 2.854±0.43 6.796±0.00 5.948±3.07 1.187±0.36 7.565±0.23

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000670 CIL_000670_0001 CGP 6:83193379-83431071
CIL_000625 CIL_000625_0002 CGP 6:83210389-83525704

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004470 IDA malic enzyme activity
GO:0004471 IEA malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473 ISS malate dehydrogenase (decarboxylating) (NADP+) activity
GO:0005515 IEA protein binding
GO:0005739 IEA mitochondrion
GO:0005829 ISS cytosol
GO:0005975 NAS carbohydrate metabolic process
GO:0006108 IDA malate metabolic process
GO:0006741 TAS NADP biosynthetic process
GO:0008948 IEA oxaloacetate decarboxylase activity
GO:0009055 TAS electron carrier activity
GO:0009725 ISS response to hormone
GO:0009743 TAS response to carbohydrate
GO:0030145 IDA manganese ion binding
GO:0043531 TAS ADP binding
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0050661 TAS NADP binding
GO:0051262 IEA protein tetramerization
GO:0051287 TAS:IEA NAD binding
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053215 me1 malic enzyme 1, NADP(+)-dependent, cytosolic protein_coding Danio_rerio
ENSDARG00000086961 ME1 (2 of 2) malic enzyme 1, NADP(+)-dependent, cytosolic protein_coding Danio_rerio
ENSMUSG00000032418 Me1 malic enzyme 1, NADP(+)-dependent, cytosolic protein_coding Mus_musculus

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