C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 4A, cAMP-specific
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000065989 PDE4A 9606 + 19:10416773-10469631 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293683 PDE4A-002 10430845-10467621 protein_coding
  ENST00000344979 PDE4A-004 10452939-10467931 protein_coding
  ENST00000380702 PDE4A-001 10420655-10469631 protein_coding
  ENST00000440014 PDE4A-003 10432435-10467621 protein_coding
  ENST00000586275 PDE4A-009 10453284-10459730 retained_intron
  ENST00000589073 PDE4A-006 10452957-10467365 nonsense_mediated_decay
  ENST00000590407 PDE4A-007 10458969-10467366 retained_intron
  ENST00000591971 PDE4A-008 10450831-10461929 protein_coding
  ENST00000592685 PDE4A-005 10416773-10467649 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000293683ENST00000344979ENST00000380702ENST00000440014ENST00000589073ENST00000590407ENST00000591971ENST00000592685
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000293683 2.522±0.00 N/A 0.343±0.00 N/A 0.407±0.00 N/A 1.147±0.00 0.499±0.00 N/A N/A 2.695±1.98 N/A 3.454±0.56
ENST00000344979 N/A N/A 1.317±0.00 N/A N/A N/A 0.090±0.00 N/A 0.217±0.00 0.854±0.00 N/A N/A 15.279±0.00
ENST00000380702 N/A N/A N/A N/A N/A N/A N/A 0.088±0.00 2.711±0.00 N/A 1.112±0.00 N/A N/A
ENST00000440014 N/A N/A 0.392±0.00 0.339±0.00 N/A 0.262±0.00 N/A N/A 0.898±0.00 1.098±0.00 N/A 1.806±0.00 N/A
ENST00000589073 N/A N/A N/A 1.472±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000590407 N/A 0.201±0.00 N/A 0.380±0.00 N/A N/A N/A N/A 0.339±0.00 N/A N/A N/A N/A
ENST00000591971 N/A N/A N/A N/A N/A N/A N/A 0.289±0.00 N/A N/A N/A N/A N/A
ENST00000592685 N/A N/A N/A N/A 0.676±0.00 N/A N/A N/A N/A N/A 1.052±0.00 N/A 5.056±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004GI CIL_0004GI_0001 CGP 19:10350529-10420121
CIL_00037J CIL_00037J_0001 CGP 19:10391134-10469631
CIL_0004FB CIL_0004FB_0001 CGP 19:10416773-10503741

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004114 IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 IDA 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006198 IEA cAMP catabolic process
GO:0007165 IEA signal transduction
GO:0007608 IEA sensory perception of smell
GO:0008152 IEA metabolic process
GO:0010738 IEA regulation of protein kinase A signaling
GO:0016020 TAS membrane
GO:0030552 IGI cAMP binding
GO:0035690 IEA cellular response to drug
GO:0042995 IEA cell projection
GO:0043949 IEA regulation of cAMP-mediated signaling
GO:0046872 IEA metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032344 pde4a phosphodiesterase 4A, cAMP-specific protein_coding Danio_rerio
ENSMUSG00000032177 Pde4a phosphodiesterase 4A, cAMP specific protein_coding Mus_musculus

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