C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: synaptotagmin I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000067715 SYT1 9606 + 12:78863993-79452008 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261205 SYT1-001 78864669-79452006 protein_coding
  ENST00000393240 SYT1-002 78863993-79450279 protein_coding
  ENST00000446242 SYT1-003 79046318-79296139 protein_coding
  ENST00000457153 SYT1-004 78864812-79452008 protein_coding
  ENST00000547046 SYT1-009 78964035-79285794 protein_coding
  ENST00000549454 SYT1-008 78868772-79217517 processed_transcript
  ENST00000549559 SYT1-013 79291799-79353542 processed_transcript
  ENST00000549671 SYT1-010 78977522-79285837 protein_coding
  ENST00000551304 SYT1-011 78977785-79285838 protein_coding
  ENST00000552074 SYT1-007 78868710-79285904 protein_coding
  ENST00000552624 SYT1-012 79045705-79296124 protein_coding
  ENST00000552744 SYT1-005 79045631-79450294 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENST00000261205ENST00000393240ENST00000457153ENST00000547046ENST00000549454ENST00000549559ENST00000552744
Transcript ID Adrenal Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000261205 0.246±0.00 70.258±3.90 0.288±0.00 0.838±0.27 N/A N/A N/A N/A 0.597±0.06 0.207±0.00 0.771±0.00
ENST00000393240 N/A N/A N/A N/A N/A N/A 0.725±0.00 N/A N/A N/A N/A
ENST00000457153 N/A 21.360±0.00 0.058±0.00 N/A 0.040±0.00 0.378±0.00 0.098±0.00 0.084±0.00 0.496±0.00 N/A 0.577±0.00
ENST00000547046 N/A N/A N/A 1.677±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000549454 N/A N/A 1.032±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000549559 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.005±0.00 N/A
ENST00000552744 N/A N/A N/A N/A N/A 0.380±0.00 N/A N/A 0.363±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002BE CIL_0002BE_0002 CGP 12:78863993-79691097

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000149 ISS SNARE binding
GO:0001786 IEA phosphatidylserine binding
GO:0005215 IEA transporter activity
GO:0005509 IEA calcium ion binding
GO:0005513 TAS detection of calcium ion
GO:0005515 IPI:IEA protein binding
GO:0005516 IEA calmodulin binding
GO:0005543 IEA phospholipid binding
GO:0005544 ISS calcium-dependent phospholipid binding
GO:0005545 TAS 1-phosphatidylinositol binding
GO:0005546 IEA phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 IEA cytoplasm
GO:0005886 TAS plasma membrane
GO:0006810 IEA transport
GO:0007268 TAS synaptic transmission
GO:0007269 TAS neurotransmitter secretion
GO:0008021 TAS synaptic vesicle
GO:0008022 IEA protein C-terminus binding
GO:0014047 TAS glutamate secretion
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016079 IEA synaptic vesicle exocytosis
GO:0017075 ISS syntaxin-1 binding
GO:0017157 TAS regulation of exocytosis
GO:0017158 IEA regulation of calcium ion-dependent exocytosis
GO:0019905 IEA syntaxin binding
GO:0030054 IEA cell junction
GO:0030141 IEA secretory granule
GO:0030276 IEA clathrin binding
GO:0030666 TAS endocytic vesicle membrane
GO:0030672 IEA synaptic vesicle membrane
GO:0031045 IEA dense core granule
GO:0031201 IEA SNARE complex
GO:0031340 IEA positive regulation of vesicle fusion
GO:0042734 IEA presynaptic membrane
GO:0042802 IEA identical protein binding
GO:0043005 ISS neuron projection
GO:0043229 IEA intracellular organelle
GO:0045956 IEA positive regulation of calcium ion-dependent exocytosis
GO:0048278 IEA vesicle docking
GO:0048306 IEA calcium-dependent protein binding
GO:0048791 ISS calcium ion-dependent exocytosis of neurotransmitter
GO:0050750 IDA low-density lipoprotein particle receptor binding
GO:0050806 ISS positive regulation of synaptic transmission
GO:0051260 TAS protein homooligomerization
GO:0051592 IEA response to calcium ion
GO:0051966 ISS regulation of synaptic transmission, glutamatergic
GO:0060076 IEA excitatory synapse
GO:0060201 TAS clathrin-sculpted acetylcholine transport vesicle membrane
GO:0060203 TAS clathrin-sculpted glutamate transport vesicle membrane
GO:0061202 TAS clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070083 TAS clathrin-sculpted monoamine transport vesicle membrane
GO:1903305 ISS regulation of regulated secretory pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030614 syt1a synaptotagmin Ia protein_coding Danio_rerio
ENSDARG00000042350 syt1b synaptotagmin Ib protein_coding Danio_rerio
ENSMUSG00000035864 Syt1 synaptotagmin I protein_coding Mus_musculus

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