C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: histone deacetylase 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000345617 HDAC4-001 ENSG00000068024 9606 - 2:239048168-239400949 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainHeartLungMuscleOvaryPlacentaTestisENST00000345617
Transcript ID Adipose Brain Heart Lung Muscle Ovary Placenta Testis
ENST00000345617 0.737±0.00 0.708±0.00 0.562±0.00 0.784±0.00 3.481±0.00 2.007±0.40 0.225±0.00 1.184±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UT CIL_0007UT_0001 VISTA 2:238792799-239398211
CIL_0003NG CIL_0003NG_0001 CGP 2:238848032-239401654

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000118 IDA:IEA histone deacetylase complex
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001047 IDA core promoter binding
GO:0001501 IEA skeletal system development
GO:0002076 IEA osteoblast development
GO:0003677 IEA DNA binding
GO:0003714 IEA transcription corepressor activity
GO:0004407 IDA:IEA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0006338 IDA chromatin remodeling
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IEA protein deacetylation
GO:0006954 TAS inflammatory response
GO:0007399 TAS nervous system development
GO:0008134 IPI transcription factor binding
GO:0008270 IDA zinc ion binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0010832 IMP negative regulation of myotube differentiation
GO:0010882 IEA regulation of cardiac muscle contraction by calcium ion signaling
GO:0014894 ISS response to denervation involved in regulation of muscle adaptation
GO:0014898 TAS cardiac muscle hypertrophy in response to stress
GO:0016568 IEA chromatin modification
GO:0016575 IDA histone deacetylation
GO:0017053 IDA transcriptional repressor complex
GO:0019901 IEA protein kinase binding
GO:0030017 IEA sarcomere
GO:0030018 IEA Z disc
GO:0030183 TAS B cell differentiation
GO:0030955 IDA potassium ion binding
GO:0031594 IEA neuromuscular junction
GO:0031672 IEA A band
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033235 IDA positive regulation of protein sumoylation
GO:0033558 IDA protein deacetylase activity
GO:0033613 IPI activating transcription factor binding
GO:0034983 IDA peptidyl-lysine deacetylation
GO:0040029 IMP regulation of gene expression, epigenetic
GO:0042113 TAS B cell activation
GO:0042493 IEA response to drug
GO:0042641 IEA actomyosin
GO:0042826 IPI histone deacetylase binding
GO:0043234 IEA protein complex
GO:0043393 IMP regulation of protein binding
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045820 ISS negative regulation of glycolytic process
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048742 IEA regulation of skeletal muscle fiber development
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153 IEA regulation of striated muscle cell differentiation
GO:0070491 IPI repressing transcription factor binding
GO:0070555 IMP response to interleukin-1
GO:0070932 IDA histone H3 deacetylation
GO:0070933 IDA histone H4 deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000097644 Hdac4-001 protein_coding Mus_musculus 0 3951
ENSMUST00000008995 Hdac4-201 protein_coding Mus_musculus 0 3862
ENSMUST00000189303 Hdac4-002 processed_transcript Mus_musculus 0 3179
ENSMUST00000187308 Hdac4-004 protein_coding Mus_musculus 0 1074
ENSDART00000036277 hdac4-201 protein_coding Danio_rerio 0 854
ENSDART00000124870 hdac4-001 protein_coding Danio_rerio 0 854
ENSMUST00000186002 Hdac4-003 protein_coding Mus_musculus 0 435
ENSDART00000111435 hdac5-201 protein_coding Danio_rerio 0 424
ENSDART00000157378 hdac5-001 protein_coding Danio_rerio 0 424
ENSMUST00000191327 Hdac4-005 retained_intron Mus_musculus 0 377

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