C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: prolyl 4-hydroxylase, alpha polypeptide II
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000072682 P4HA2 9606 - 5:132191838-132295315 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000166534 P4HA2-003 132192610-132227857 protein_coding
  ENST00000360568 P4HA2-002 132192610-132228082 protein_coding
  ENST00000379086 P4HA2-004 132192610-132227819 protein_coding
  ENST00000379100 P4HA2-201 132192613-132227242 protein_coding
  ENST00000379104 P4HA2-202 132192613-132227242 protein_coding
  ENST00000395164 P4HA2-017 132210490-132222091 protein_coding
  ENST00000401867 P4HA2-001 132191838-132227815 protein_coding
  ENST00000416053 P4HA2-011 132217223-132277600 protein_coding
  ENST00000417528 P4HA2-010 132210380-132227794 protein_coding
  ENST00000418055 P4HA2-016 132214041-132227835 protein_coding
  ENST00000428369 P4HA2-009 132213945-132227378 protein_coding
  ENST00000428841 P4HA2-018 132217779-132228258 protein_coding
  ENST00000431054 P4HA2-014 132210381-132295271 protein_coding
  ENST00000439698 P4HA2-015 132210441-132277855 protein_coding
  ENST00000453286 P4HA2-005 132213924-132227839 protein_coding
  ENST00000467587 P4HA2-008 132193041-132195730 retained_intron
  ENST00000471826 P4HA2-013 132248907-132295315 processed_transcript
  ENST00000474628 P4HA2-007 132192671-132195258 retained_intron
  ENST00000478055 P4HA2-006 132217197-132227262 retained_intron
  ENST00000481636 P4HA2-012 132277209-132277922 processed_transcript
  ENST00000506807 P4HA2-019 132192986-132193568 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000166534ENST00000360568ENST00000379086ENST00000379100ENST00000401867ENST00000474628
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000166534 3.400±0.00 N/A 2.971±0.00 1.066±0.13 3.876±0.20 2.446±1.25 3.453±0.04 N/A N/A 5.467±1.51 0.759±0.00 4.898±2.38 4.424±0.00 5.111±1.16
ENST00000360568 4.402±0.00 5.157±0.00 N/A 1.822±0.13 7.284±0.00 17.489±0.00 8.496±0.00 11.146±0.00 1.482±0.27 13.856±0.00 1.601±0.00 4.157±0.82 14.004±1.99 6.975±2.74
ENST00000379086 N/A N/A N/A N/A N/A 4.321±0.00 N/A 4.023±3.03 6.704±0.00 3.445±0.00 4.446±0.00 4.738±2.58 12.991±0.63 N/A
ENST00000379100 N/A N/A N/A N/A N/A 0.790±0.00 1.024±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000401867 N/A N/A N/A 0.473±0.00 N/A N/A N/A N/A 0.976±0.00 N/A N/A 1.628±0.70 2.595±0.11 1.735±0.00
ENST00000474628 N/A N/A N/A N/A N/A N/A N/A N/A 1.816±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00093D CIL_00093D_0001 VISTA 5:131965137-132566411
CIL_0007RF CIL_0007RF_0001 VISTA 5:131967147-132570227

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004656 IEA procollagen-proline 4-dioxygenase activity
GO:0005506 IEA iron ion binding
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005783 IDA:IEA endoplasmic reticulum
GO:0009055 TAS electron carrier activity
GO:0016222 IEA procollagen-proline 4-dioxygenase complex
GO:0016491 IEA oxidoreductase activity
GO:0016702 IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0018401 IEA peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0019511 IEA peptidyl-proline hydroxylation
GO:0031418 IEA L-ascorbic acid binding
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010085 p4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 protein_coding Danio_rerio
ENSMUSG00000018906 P4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide protein_coding Mus_musculus

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