C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000018906 P4ha2 10090 + 11:54100095-54131665 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000019050 P4ha2-002 54100963-54131652 protein_coding
  ENSMUST00000093107 P4ha2-001 54100924-54131652 protein_coding
  ENSMUST00000125132 P4ha2-005 54101068-54111574 nonsense_mediated_decay
  ENSMUST00000125651 P4ha2-003 54100963-54127762 retained_intron
  ENSMUST00000126840 P4ha2-013 54100991-54111563 protein_coding
  ENSMUST00000129499 P4ha2-010 54100980-54110314 protein_coding
  ENSMUST00000135596 P4ha2-011 54100975-54111635 retained_intron
  ENSMUST00000135653 P4ha2-006 54101245-54111574 protein_coding
  ENSMUST00000138477 P4ha2-015 54107320-54114274 protein_coding
  ENSMUST00000139315 P4ha2-004 54127693-54131665 retained_intron
  ENSMUST00000141258 P4ha2-007 54111021-54120246 nonsense_mediated_decay
  ENSMUST00000142583 P4ha2-012 54124673-54126062 retained_intron
  ENSMUST00000151218 P4ha2-009 54100095-54114184 protein_coding
  ENSMUST00000155299 P4ha2-008 54113203-54114274 processed_transcript
  ENSMUST00000174616 P4ha2-016 54100975-54131662 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000019050ENSMUST00000093107ENSMUST00000125651ENSMUST00000138477ENSMUST00000139315ENSMUST00000174616
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000019050 4.106±1.31 1.252±0.37 4.057±0.11 2.333±2.23 3.106±1.14 1.479±0.88 7.163±1.20 2.118±0.57 0.826±0.56 4.361±0.77 5.730±0.93 2.761±1.22 25.767±10.79 0.913±0.34
ENSMUST00000093107 7.857±0.54 2.243±1.06 3.115±0.30 0.713±0.02 2.814±1.21 0.946±0.21 6.029±1.88 4.289±0.74 1.193±0.86 4.586±0.63 1.880±0.40 2.525±0.39 25.511±11.83 0.869±0.12
ENSMUST00000125651 3.423±1.63 1.310±0.42 1.363±0.01 1.417±1.10 1.828±0.35 0.882±0.19 2.352±0.32 1.179±0.21 0.196±0.00 3.646±0.42 1.481±0.00 2.082±0.48 N/A 0.505±0.11
ENSMUST00000138477 N/A 5.065±0.59 N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.956±0.62 N/A N/A
ENSMUST00000139315 1.758±0.00 1.159±0.07 1.323±0.00 0.880±0.33 1.664±0.15 0.895±0.21 2.460±0.32 N/A 0.268±0.05 3.002±0.78 N/A 4.065±1.60 N/A 0.864±0.00
ENSMUST00000174616 5.052±0.01 1.032±0.00 2.159±0.00 0.798±0.14 2.226±0.30 1.794±0.34 3.391±0.59 2.716±0.89 1.451±0.46 5.948±0.00 1.827±0.48 4.409±0.64 22.198±14.49 1.021±0.34

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007RF CIL_0007RF_0002 VISTA 11:53756663-54359415
CIL_00093D CIL_00093D_0002 VISTA 11:53760072-54361368

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004656 IDA procollagen-proline 4-dioxygenase activity
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005581 IEA collagen trimer
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0016222 IDA procollagen-proline 4-dioxygenase complex
GO:0016702 IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0018401 IDA peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0031418 IEA L-ascorbic acid binding
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010085 p4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 protein_coding Danio_rerio
ENSG00000072682 P4HA2 prolyl 4-hydroxylase, alpha polypeptide II protein_coding Homo_sapiens

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