C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cadherin, EGF LAG seven-pass G-type receptor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000075275 CELSR1 9606 - 22:46360834-46537170 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262738 CELSR1-001 46360834-46537170 protein_coding
  ENST00000454637 CELSR1-002 46462780-46535294 protein_coding
  ENST00000468025 CELSR1-005 46372913-46377624 processed_transcript
  ENST00000473624 CELSR1-003 46361174-46365380 retained_intron
  ENST00000497509 CELSR1-004 46530308-46534200 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262738ENST00000454637ENST00000473624
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262738 0.287±0.00 2.122±0.00 1.768±0.00 0.052±0.03 0.634±0.00 0.184±0.05 0.807±0.68 2.330±0.00 0.128±0.09 2.081±1.00 N/A 2.837±1.26 0.656±0.09 0.770±0.00
ENST00000454637 N/A N/A N/A N/A N/A 0.476±0.00 N/A N/A N/A N/A 0.039±0.00 N/A N/A N/A
ENST00000473624 N/A 2.979±0.00 N/A N/A 0.348±0.00 N/A N/A 1.783±0.00 N/A 3.862±0.00 0.005±0.00 1.976±0.39 0.337±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00024N CIL_00024N_0001 CGP 22:46330875-46537170
CIL_0008BF CIL_0008BF_0001 VISTA 22:46352708-46954203
CIL_0000V3 CIL_0000V3_0002 CGP 22:46360834-46679790

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001736 ISS establishment of planar polarity
GO:0001764 IEA neuron migration
GO:0001843 ISS neural tube closure
GO:0001942 IEA hair follicle development
GO:0004888 NAS:IEA transmembrane signaling receptor activity
GO:0004930 NAS:IEA G-protein coupled receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0007156 IEA homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007186 NAS:IEA G-protein coupled receptor signaling pathway
GO:0007218 IEA neuropeptide signaling pathway
GO:0007266 IEA Rho protein signal transduction
GO:0007417 TAS central nervous system development
GO:0007626 IEA locomotory behavior
GO:0009952 IEA anterior/posterior pattern specification
GO:0016020 IEA membrane
GO:0016021 TAS:IEA integral component of membrane
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0042060 IEA wound healing
GO:0042249 IEA establishment of planar polarity of embryonic epithelium
GO:0042472 IEA inner ear morphogenesis
GO:0045176 IEA apical protein localization
GO:0046983 NAS protein dimerization activity
GO:0048105 IEA establishment of body hair planar orientation
GO:0060488 IEA orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060489 IEA planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
GO:0060490 IEA lateral sprouting involved in lung morphogenesis
GO:0090179 IEA planar cell polarity pathway involved in neural tube closure
GO:0090251 IEA protein localization involved in establishment of planar polarity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058259 celsr1b cadherin EGF LAG seven-pass G-type receptor 1b protein_coding Danio_rerio
ENSDARG00000069185 celsr1a cadherin EGF LAG seven-pass G-type receptor 1a protein_coding Danio_rerio
ENSMUSG00000016028 Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) protein_coding Mus_musculus

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