C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myocyte enhancer factor 2C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000081189 MEF2C 9606 - 5:88718158-88904105 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000340208 MEF2C-005 88718158-88904082 protein_coding
  ENST00000424173 MEF2C-004 88718222-88904105 protein_coding
  ENST00000437473 MEF2C-003 88720349-88883233 protein_coding
  ENST00000502831 MEF2C-007 88761292-88904105 protein_coding
  ENST00000502983 MEF2C-010 88761200-88884568 protein_coding
  ENST00000503075 MEF2C-013 88761325-88883227 protein_coding
  ENST00000503554 MEF2C-019 88731896-88785542 processed_transcript
  ENST00000503955 MEF2C-008 88887392-88904052 retained_intron
  ENST00000504921 MEF2C-201 88718242-88823927 protein_coding
  ENST00000506554 MEF2C-025 88720844-88883172 protein_coding
  ENST00000506716 MEF2C-016 88731852-88824340 protein_coding
  ENST00000507984 MEF2C-015 88761023-88827158 protein_coding
  ENST00000508569 MEF2C-022 88722574-88883159 protein_coding
  ENST00000508610 MEF2C-014 88761209-88877977 protein_coding
  ENST00000509349 MEF2C-011 88823861-88883224 processed_transcript
  ENST00000509373 MEF2C-017 88804770-88824275 protein_coding
  ENST00000510942 MEF2C-024 88720825-88883172 protein_coding
  ENST00000510980 MEF2C-021 88722837-88729519 retained_intron
  ENST00000511086 MEF2C-018 88804526-88883174 retained_intron
  ENST00000513252 MEF2C-012 88731807-88883147 protein_coding
  ENST00000514015 MEF2C-023 88722595-88883224 protein_coding
  ENST00000514028 MEF2C-001 88720349-88883214 protein_coding
  ENST00000515093 MEF2C-006 88823796-88889324 processed_transcript
  ENST00000515715 MEF2C-020 88731444-88749124 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000424173ENST00000437473ENST00000504921ENST00000506554ENST00000508569ENST00000510942ENST00000511086ENST00000514015
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000424173 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.141±0.85 N/A N/A 1.792±0.00
ENST00000437473 N/A N/A 1.357±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000504921 6.572±0.00 7.340±0.00 N/A 17.788±0.00 N/A 2.951±0.00 4.313±0.00 2.766±0.00 0.663±0.00 3.493±2.08 3.216±0.00 2.544±0.27 3.057±0.17 1.491±0.00
ENST00000506554 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.177±0.00 N/A
ENST00000508569 N/A N/A N/A N/A N/A N/A 4.308±0.00 0.838±0.00 N/A 6.704±3.08 10.559±0.00 1.258±0.00 7.545±0.00 4.833±0.00
ENST00000510942 5.300±0.00 5.117±0.00 0.980±0.00 N/A 3.658±0.00 2.281±0.49 N/A 0.731±0.00 6.515±0.00 4.859±0.15 8.054±0.39 2.485±0.00 2.173±0.00 2.944±0.00
ENST00000511086 N/A N/A N/A N/A N/A 5.412±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000514015 N/A N/A N/A N/A N/A 2.981±0.00 N/A N/A N/A N/A N/A 1.152±0.00 3.274±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005KE CIL_0005KE_0002 CGP 5:88189633-88904105
CIL_0008B9 CIL_0008B9_0001 VISTA 5:88583640-89184171
CIL_0007M9 CIL_0007M9_0002 UCNEbase 5:88678048-89377026

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IMP MAPK cascade
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IEA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 ISS sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000983 IDA RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000987 IEA core promoter proximal region sequence-specific DNA binding
GO:0001046 IEA core promoter sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001568 ISS blood vessel development
GO:0001649 ISS osteoblast differentiation
GO:0001764 ISS neuron migration
GO:0001782 ISS B cell homeostasis
GO:0001947 ISS heart looping
GO:0001958 ISS endochondral ossification
GO:0001974 ISS blood vessel remodeling
GO:0002062 ISS chondrocyte differentiation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002467 ISS germinal center formation
GO:0002634 ISS regulation of germinal center formation
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0002931 ISS response to ischemia
GO:0003138 ISS primary heart field specification
GO:0003139 ISS secondary heart field specification
GO:0003151 ISS outflow tract morphogenesis
GO:0003185 ISS sinoatrial valve morphogenesis
GO:0003211 ISS cardiac ventricle formation
GO:0003677 IDA:IEA DNA binding
GO:0003680 IDA AT DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA:IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 ISS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006915 IEA apoptotic process
GO:0006959 ISS humoral immune response
GO:0007399 TAS nervous system development
GO:0007507 ISS heart development
GO:0007517 TAS muscle organ development
GO:0007519 ISS skeletal muscle tissue development
GO:0007521 ISS muscle cell fate determination
GO:0007611 ISS learning or memory
GO:0009615 IEP response to virus
GO:0010628 IDA positive regulation of gene expression
GO:0010629 ISS negative regulation of gene expression
GO:0010694 ISS positive regulation of alkaline phosphatase activity
GO:0014033 ISS neural crest cell differentiation
GO:0014898 IEA cardiac muscle hypertrophy in response to stress
GO:0014902 IEP myotube differentiation
GO:0016607 IDA nuclear speck
GO:0030182 ISS neuron differentiation
GO:0030220 ISS platelet formation
GO:0030224 IEA monocyte differentiation
GO:0030279 IDA negative regulation of ossification
GO:0030318 ISS melanocyte differentiation
GO:0030501 ISS positive regulation of bone mineralization
GO:0030890 ISS positive regulation of B cell proliferation
GO:0033613 IPI activating transcription factor binding
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035198 IDA miRNA binding
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035690 ISS cellular response to drug
GO:0035984 ISS cellular response to trichostatin A
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042100 ISS B cell proliferation
GO:0042692 TAS muscle cell differentiation
GO:0042826 IEA histone deacetylase binding
GO:0043234 IDA protein complex
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043523 ISS regulation of neuron apoptotic process
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045087 TAS innate immune response
GO:0045165 IEA cell fate commitment
GO:0045652 ISS regulation of megakaryocyte differentiation
GO:0045663 IMP positive regulation of myoblast differentiation
GO:0045666 ISS positive regulation of neuron differentiation
GO:0045669 ISS positive regulation of osteoblast differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046928 ISS regulation of neurotransmitter secretion
GO:0046982 IPI protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048167 ISS regulation of synaptic plasticity
GO:0048643 IMP positive regulation of skeletal muscle tissue development
GO:0048666 ISS neuron development
GO:0048667 ISS cell morphogenesis involved in neuron differentiation
GO:0048703 IEA embryonic viscerocranium morphogenesis
GO:0048704 IEA embryonic skeletal system morphogenesis
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050853 ISS B cell receptor signaling pathway
GO:0051145 ISS smooth muscle cell differentiation
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051403 TAS stress-activated MAPK cascade
GO:0051963 ISS regulation of synapse assembly
GO:0051966 ISS regulation of synaptic transmission, glutamatergic
GO:0055007 IEA cardiac muscle cell differentiation
GO:0055012 ISS ventricular cardiac muscle cell differentiation
GO:0060021 IEA palate development
GO:0060025 ISS regulation of synaptic activity
GO:0060045 ISS positive regulation of cardiac muscle cell proliferation
GO:0060079 ISS regulation of excitatory postsynaptic membrane potential
GO:0060297 IEA regulation of sarcomere organization
GO:0060536 IEA cartilage morphogenesis
GO:0060998 ISS regulation of dendritic spine development
GO:0061333 ISS renal tubule morphogenesis
GO:0071222 ISS cellular response to lipopolysaccharide
GO:0071277 ISS cellular response to calcium ion
GO:0071374 IDA cellular response to parathyroid hormone stimulus
GO:0071498 ISS cellular response to fluid shear stress
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0071837 IEA HMG box domain binding
GO:0071864 IEA positive regulation of cell proliferation in bone marrow
GO:0072102 ISS glomerulus morphogenesis
GO:0072160 ISS nephron tubule epithelial cell differentiation
GO:0090073 ISS positive regulation of protein homodimerization activity
GO:2000111 ISS positive regulation of macrophage apoptotic process
GO:2000310 ISS regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 ISS regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000727 IDA positive regulation of cardiac muscle cell differentiation
GO:2000987 ISS positive regulation of behavioral fear response
GO:2001013 ISS epithelial cell proliferation involved in renal tubule morphogenesis
GO:2001016 IDA positive regulation of skeletal muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009418 mef2cb myocyte enhancer factor 2cb protein_coding Danio_rerio
ENSMUSG00000005583 Mef2c myocyte enhancer factor 2C protein_coding Mus_musculus

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