C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myocyte enhancer factor 2C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000005583 Mef2c 10090 + 13:83504034-83667079 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000005722 Mef2c-201 83504034-83667079 protein_coding
  ENSMUST00000163888 Mef2c-202 83504034-83667079 protein_coding
  ENSMUST00000185052 Mef2c-001 83573607-83664472 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000005722ENSMUST00000163888ENSMUST00000185052
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000005722 1.129±0.00 0.568±0.00 0.987±0.00 1.168±0.22 2.894±0.00 N/A 1.452±0.00 0.705±0.00 0.274±0.00 N/A 38.086±3.46 N/A N/A 0.096±0.00
ENSMUST00000163888 2.046±0.55 0.883±0.12 3.520±0.00 4.666±0.21 5.271±0.80 0.489±0.13 2.609±0.35 0.737±0.27 0.162±0.22 2.902±0.63 30.402±3.33 2.046±0.37 0.215±0.00 0.116±0.00
ENSMUST00000185052 2.084±0.95 7.241±1.75 N/A 10.491±9.13 10.420±2.97 2.352±0.18 2.777±0.00 1.288±0.29 0.195±0.07 4.151±0.72 N/A 9.927±2.49 0.242±0.00 0.666±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008B9 CIL_0008B9_0002 VISTA 13:83223874-83824381
CIL_0007M9 CIL_0007M9_0005 UCNEbase 13:83484793-83885112

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000165 IDA MAPK cascade
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000983 ISS RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001568 IMP blood vessel development
GO:0001649 IGI osteoblast differentiation
GO:0001764 IMP neuron migration
GO:0001782 IMP B cell homeostasis
GO:0001947 IMP heart looping
GO:0001958 IGI endochondral ossification
GO:0001974 IMP blood vessel remodeling
GO:0002062 IGI chondrocyte differentiation
GO:0002467 IMP germinal center formation
GO:0002634 IMP regulation of germinal center formation
GO:0002931 ISS response to ischemia
GO:0003138 IMP primary heart field specification
GO:0003139 IMP secondary heart field specification
GO:0003151 IGI outflow tract morphogenesis
GO:0003185 IMP sinoatrial valve morphogenesis
GO:0003211 IMP cardiac ventricle formation
GO:0003677 IDA DNA binding
GO:0003680 IEA AT DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 ISS cytoplasm
GO:0005829 ISS cytosol
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006915 IEA apoptotic process
GO:0006959 IMP humoral immune response
GO:0007507 IMP heart development
GO:0007519 IMP skeletal muscle tissue development
GO:0007521 IMP muscle cell fate determination
GO:0007611 IMP learning or memory
GO:0009615 IEA response to virus
GO:0010628 IMP positive regulation of gene expression
GO:0010629 IMP negative regulation of gene expression
GO:0010694 IMP positive regulation of alkaline phosphatase activity
GO:0014033 IMP neural crest cell differentiation
GO:0014898 IMP cardiac muscle hypertrophy in response to stress
GO:0014902 IEA myotube differentiation
GO:0016607 ISS nuclear speck
GO:0030182 IMP neuron differentiation
GO:0030220 IMP platelet formation
GO:0030224 IMP monocyte differentiation
GO:0030279 ISS negative regulation of ossification
GO:0030318 IMP melanocyte differentiation
GO:0030501 IMP positive regulation of bone mineralization
GO:0030890 IMP positive regulation of B cell proliferation
GO:0033613 IEA activating transcription factor binding
GO:0035198 ISS miRNA binding
GO:0035690 IDA cellular response to drug
GO:0035914 NAS skeletal muscle cell differentiation
GO:0035984 IDA cellular response to trichostatin A
GO:0042100 IMP B cell proliferation
GO:0042826 IPI histone deacetylase binding
GO:0043234 ISS protein complex
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043523 IMP regulation of neuron apoptotic process
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045165 IMP cell fate commitment
GO:0045652 IMP regulation of megakaryocyte differentiation
GO:0045663 ISS positive regulation of myoblast differentiation
GO:0045666 IDA positive regulation of neuron differentiation
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046928 IMP regulation of neurotransmitter secretion
GO:0046982 IEA protein heterodimerization activity
GO:0048167 IMP regulation of synaptic plasticity
GO:0048643 ISS positive regulation of skeletal muscle tissue development
GO:0048666 IMP neuron development
GO:0048667 IMP cell morphogenesis involved in neuron differentiation
GO:0048703 IMP embryonic viscerocranium morphogenesis
GO:0048704 IMP embryonic skeletal system morphogenesis
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0050853 IMP B cell receptor signaling pathway
GO:0051145 IMP smooth muscle cell differentiation
GO:0051963 IMP regulation of synapse assembly
GO:0051966 IMP regulation of synaptic transmission, glutamatergic
GO:0055007 IGI cardiac muscle cell differentiation
GO:0055012 IMP ventricular cardiac muscle cell differentiation
GO:0060021 IGI palate development
GO:0060025 IMP regulation of synaptic activity
GO:0060045 IMP positive regulation of cardiac muscle cell proliferation
GO:0060079 IMP regulation of excitatory postsynaptic membrane potential
GO:0060297 IMP regulation of sarcomere organization
GO:0060536 IMP cartilage morphogenesis
GO:0060998 IMP regulation of dendritic spine development
GO:0061333 IMP renal tubule morphogenesis
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071277 IDA cellular response to calcium ion
GO:0071374 ISS cellular response to parathyroid hormone stimulus
GO:0071498 IDA cellular response to fluid shear stress
GO:0071560 ISS cellular response to transforming growth factor beta stimulus
GO:0071837 IPI HMG box domain binding
GO:0071864 IGI positive regulation of cell proliferation in bone marrow
GO:0072102 IMP glomerulus morphogenesis
GO:0072160 IMP nephron tubule epithelial cell differentiation
GO:0090073 IDA positive regulation of protein homodimerization activity
GO:2000111 IMP positive regulation of macrophage apoptotic process
GO:2000310 IMP regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 IMP regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000727 IMP positive regulation of cardiac muscle cell differentiation
GO:2000987 IMP positive regulation of behavioral fear response
GO:2001013 IMP epithelial cell proliferation involved in renal tubule morphogenesis
GO:2001016 IEA positive regulation of skeletal muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009418 mef2cb myocyte enhancer factor 2cb protein_coding Danio_rerio
ENSG00000081189 MEF2C myocyte enhancer factor 2C protein_coding Homo_sapiens

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