C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: RE1-silencing transcription factor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000309042 REST-001 ENSG00000084093 9606 + 4:56907909-56935844 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryTestisENST00000309042
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Testis
ENST00000309042 2.728±0.00 1.390±0.00 1.540±0.00 0.275±0.05 3.136±0.00 1.453±0.38 1.964±0.36 1.104±0.44 1.150±0.00 1.328±0.34 1.000±0.77 2.347±0.46 2.833±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008G9 CIL_0008G9_0001 VISTA 4:56396035-56999166
CIL_0001WS CIL_0001WS_0001 CGP 4:56809860-56935844
CIL_0003EC CIL_0003EC_0002 CGP 4:56907876-56978823

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001047 IDA core promoter binding
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0003677 IEA DNA binding
GO:0003682 ISS chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005829 IEA cytosol
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008134 IPI transcription factor binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0010629 IMP negative regulation of gene expression
GO:0015271 IMP outward rectifier potassium channel activity
GO:0017053 IDA transcriptional repressor complex
GO:0032348 IMP negative regulation of aldosterone biosynthetic process
GO:0035690 IMP cellular response to drug
GO:0043065 IMP positive regulation of apoptotic process
GO:0043280 IMP positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922 IDA negative regulation by host of viral transcription
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045665 IMP negative regulation of neuron differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045955 ISS negative regulation of calcium ion-dependent exocytosis
GO:0046676 IMP negative regulation of insulin secretion
GO:0046872 IEA metal ion binding
GO:0050768 ISS negative regulation of neurogenesis
GO:0060379 ISS cardiac muscle cell myoblast differentiation
GO:0070933 IDA histone H4 deacetylation
GO:0071257 IMP cellular response to electrical stimulus
GO:0071385 IDA cellular response to glucocorticoid stimulus
GO:0071805 IMP potassium ion transmembrane transport
GO:2000065 IMP negative regulation of cortisol biosynthetic process
GO:2000706 ISS negative regulation of dense core granule biogenesis
GO:2000740 IMP negative regulation of mesenchymal stem cell differentiation
GO:2000798 IMP negative regulation of amniotic stem cell differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000080359 Rest-001 protein_coding Mus_musculus 0 1382
ENSMUST00000113449 Rest-002 protein_coding Mus_musculus 0 1306

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