C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aldo-keto reductase family 1, member B1 (aldose reductase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000085662 AKR1B1 9606 - 7:134442350-134459284 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000285930 AKR1B1-001 134442350-134459142 protein_coding
  ENST00000426422 AKR1B1-009 134449719-134459098 nonsense_mediated_decay
  ENST00000434222 AKR1B1-002 134442386-134459102 nonsense_mediated_decay
  ENST00000462784 AKR1B1-007 134451294-134459134 retained_intron
  ENST00000465351 AKR1B1-003 134442387-134459102 retained_intron
  ENST00000467251 AKR1B1-015 134444727-134448024 retained_intron
  ENST00000467829 AKR1B1-006 134449685-134459284 retained_intron
  ENST00000484592 AKR1B1-011 134449578-134459130 retained_intron
  ENST00000487438 AKR1B1-005 134448997-134459192 processed_transcript
  ENST00000489022 AKR1B1-014 134449055-134459129 processed_transcript
  ENST00000491741 AKR1B1-004 134449058-134459284 retained_intron
  ENST00000497983 AKR1B1-013 134449096-134459252 processed_transcript
  ENST00000498373 AKR1B1-012 134447956-134449332 retained_intron
  ENST00000498771 AKR1B1-010 134447850-134451806 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000285930ENST00000434222ENST00000465351ENST00000491741ENST00000498373ENST00000498771
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000285930 37.712±0.00 42.435±0.00 4.560±0.00 24.819±21.61 14.040±11.80 11.606±10.47 33.149±27.34 54.082±53.29 4.821±3.52 25.640±0.00 31.774±21.66 29.662±20.30 133.418±65.13 43.922±10.60
ENST00000434222 N/A N/A N/A N/A N/A 0.603±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000465351 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.603±0.00 N/A 4.696±0.00 N/A N/A
ENST00000491741 N/A N/A N/A N/A 0.758±0.00 N/A N/A N/A N/A N/A N/A 1.775±1.15 N/A N/A
ENST00000498373 N/A N/A 5.649±0.00 N/A N/A N/A N/A N/A N/A 5.276±0.00 11.181±0.00 N/A N/A N/A
ENST00000498771 N/A N/A 2.720±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.717±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002GW CIL_0002GW_0001 CGP 7:134289332-134459284
CIL_0002GX CIL_0002GX_0001 CGP 7:134442350-134541408

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004032 IEA alditol:NADP+ 1-oxidoreductase activity
GO:0004033 TAS aldo-keto reductase (NADP) activity
GO:0005615 TAS extracellular space
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005975 TAS carbohydrate metabolic process
GO:0006700 TAS C21-steroid hormone biosynthetic process
GO:0006950 TAS response to stress
GO:0008202 TAS steroid metabolic process
GO:0009055 TAS electron carrier activity
GO:0016491 IEA oxidoreductase activity
GO:0043795 IDA glyceraldehyde oxidoreductase activity
GO:0044281 TAS small molecule metabolic process
GO:0044597 IMP daunorubicin metabolic process
GO:0044598 IMP doxorubicin metabolic process
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045598 si:dkey-180p18.9 aldo-keto reductase family 1, member B1 (aldose reductase) protein_coding Danio_rerio
ENSMUSG00000001642 Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) protein_coding Mus_musculus

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