C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: T-box 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000089225 TBX5 9606 - 12:114353931-114408442 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000310346 TBX5-001 114353931-114408442 protein_coding
  ENST00000349716 TBX5-003 114353931-114408387 protein_coding
  ENST00000405440 TBX5-005 114355381-114406084 protein_coding
  ENST00000526441 TBX5-002 114366097-114403898 protein_coding
  ENST00000552726 TBX5-006 114394878-114403949 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastHeartLungMuscleOvaryPlacentaTestisENST00000310346ENST00000349716ENST00000405440
Transcript ID Adipose Brain Breast Heart Lung Muscle Ovary Placenta Testis
ENST00000310346 N/A N/A N/A N/A 1.491±0.00 N/A 0.006±0.00 2.140±0.00 N/A
ENST00000349716 0.132±0.00 0.042±0.00 0.035±0.00 N/A 1.467±0.00 0.060±0.00 0.089±0.04 N/A N/A
ENST00000405440 0.121±0.00 0.034±0.00 0.590±0.40 4.736±3.64 2.321±1.13 0.115±0.00 0.126±0.00 N/A 0.050±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008CB CIL_0008CB_0001 VISTA 12:113922562-114523201
CIL_00095S CIL_00095S_0001 VISTA 12:114119731-114721669
CIL_00092A CIL_00092A_0001 VISTA 12:114147407-114748589

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002009 IEA morphogenesis of an epithelium
GO:0003166 IEA bundle of His development
GO:0003181 IEA atrioventricular valve morphogenesis
GO:0003197 IEA endocardial cushion development
GO:0003218 ISS cardiac left ventricle formation
GO:0003229 IEA ventricular cardiac muscle tissue development
GO:0003281 ISS ventricular septum development
GO:0003283 IEA atrial septum development
GO:0003677 IDA DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007267 IDA cell-cell signaling
GO:0007389 IEA pattern specification process
GO:0007507 IDA heart development
GO:0008134 IPI transcription factor binding
GO:0008285 IDA negative regulation of cell proliferation
GO:0010467 TAS gene expression
GO:0010719 TAS negative regulation of epithelial to mesenchymal transition
GO:0030262 IDA apoptotic nuclear changes
GO:0030324 IEA lung development
GO:0030326 IMP embryonic limb morphogenesis
GO:0030336 IDA negative regulation of cell migration
GO:0035115 IMP embryonic forelimb morphogenesis
GO:0035136 IMP forelimb morphogenesis
GO:0043565 IDA sequence-specific DNA binding
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0051891 IDA positive regulation of cardioblast differentiation
GO:0055007 IEA cardiac muscle cell differentiation
GO:0060039 IDA pericardium development
GO:0060044 IDA negative regulation of cardiac muscle cell proliferation
GO:0060045 IEA positive regulation of cardiac muscle cell proliferation
GO:0060413 IEA atrial septum morphogenesis
GO:0060980 TAS cell migration involved in coronary vasculogenesis
GO:0072513 IEA positive regulation of secondary heart field cardioblast proliferation
GO:1900117 IC regulation of execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024894 tbx5a T-box 5a protein_coding Danio_rerio
ENSMUSG00000018263 Tbx5 T-box 5 protein_coding Mus_musculus

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