C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: NLR family, CARD domain containing 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000404025 NLRC4-001 ENSG00000091106 9606 - 2:32224456-32265854 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalHeartLiverENST00000404025
Transcript ID Adipose Adrenal Heart Liver
ENST00000404025 0.368±0.00 0.111±0.00 0.123±0.00 0.243±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000MX CIL_0000MX_0001 CGP 2:32165841-32265854
CIL_0000MY CIL_0000MY_0001 CGP 2:32224453-32316594

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 TAS magnesium ion binding
GO:0002218 ISS activation of innate immune response
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005622 NAS intracellular
GO:0005829 ISS cytosol
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 ISS inflammatory response
GO:0016045 IDA detection of bacterium
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042742 IDA defense response to bacterium
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043065 IDA positive regulation of apoptotic process
GO:0043281 IEA regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 TAS innate immune response
GO:0050702 IDA interleukin-1 beta secretion
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051260 ISS protein homooligomerization
GO:0070269 ISS pyroptosis
GO:0072557 ISS IPAF inflammasome complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000052124 Nlrc4-201 protein_coding Mus_musculus 0 2314

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