C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neuropilin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000099250 NRP1 9606 - 10:33177492-33336262 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265371 NRP1-001 33177492-33336262 protein_coding
  ENST00000374816 NRP1-201 33205449-33334522 protein_coding
  ENST00000374821 NRP1-004 33197621-33334522 protein_coding
  ENST00000374822 NRP1-003 33197621-33334642 protein_coding
  ENST00000374823 NRP1-005 33201018-33334382 protein_coding
  ENST00000374867 NRP1-202 33177494-33334905 protein_coding
  ENST00000374875 NRP1-002 33177492-33334636 protein_coding
  ENST00000395995 NRP1-203 33177494-33334905 protein_coding
  ENST00000413802 NRP1-009 33179897-33185655 protein_coding
  ENST00000418675 NRP1-008 33194367-33202995 protein_coding
  ENST00000431894 NRP1-007 33195424-33207625 protein_coding
  ENST00000432372 NRP1-006 33211410-33335078 protein_coding
  ENST00000455749 NRP1-011 33249414-33263704 protein_coding
  ENST00000466932 NRP1-010 33194372-33213561 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265371ENST00000374867ENST00000374875ENST00000395995ENST00000413802
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265371 N/A N/A N/A 1.705±0.00 N/A N/A 1.781±0.00 N/A N/A 8.824±0.00 N/A N/A N/A N/A
ENST00000374867 36.961±0.00 12.116±0.00 3.563±0.00 N/A 12.470±5.01 3.986±2.57 5.650±2.30 4.664±1.93 5.809±1.56 6.317±0.00 1.384±0.44 8.003±6.54 17.346±6.72 2.149±1.37
ENST00000374875 36.031±0.00 22.294±0.00 4.199±0.00 1.526±1.02 15.443±10.04 10.733±7.48 3.927±0.46 10.658±8.49 3.494±1.19 18.791±0.00 3.038±0.00 5.585±4.31 15.473±1.67 7.249±6.20
ENST00000395995 N/A N/A N/A N/A 3.005±0.00 12.693±0.00 N/A 8.921±0.00 N/A N/A 2.018±0.00 N/A 10.653±0.00 2.107±1.35
ENST00000413802 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.582±0.00 62.823±0.00 5.699±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006FV CIL_0006FV_0002 CGP 10:32900319-33336262

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IMP:IEA angiogenesis
GO:0001569 ISS patterning of blood vessels
GO:0001764 ISS neuron migration
GO:0001938 TAS positive regulation of endothelial cell proliferation
GO:0002040 ISS sprouting angiogenesis
GO:0002042 ISS cell migration involved in sprouting angiogenesis
GO:0002116 NAS semaphorin receptor complex
GO:0005021 ISS:IEA vascular endothelial growth factor-activated receptor activity
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005769 ISS early endosome
GO:0005829 IDA cytosol
GO:0005883 IEA neurofilament
GO:0005886 IDA plasma membrane
GO:0005925 IDA focal adhesion
GO:0007155 IEA cell adhesion
GO:0007165 TAS signal transduction
GO:0007267 TAS cell-cell signaling
GO:0007411 NAS:IEA axon guidance
GO:0007413 IEA axonal fasciculation
GO:0007507 IEA heart development
GO:0008045 IEA motor neuron axon guidance
GO:0008201 IEA heparin binding
GO:0009611 IEA response to wounding
GO:0009887 IEA organ morphogenesis
GO:0009986 IEA cell surface
GO:0010595 TAS positive regulation of endothelial cell migration
GO:0014911 TAS positive regulation of smooth muscle cell migration
GO:0015026 TAS coreceptor activity
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016358 IEA dendrite development
GO:0016477 IEA cell migration
GO:0017154 NAS:IEA semaphorin receptor activity
GO:0019838 TAS growth factor binding
GO:0019955 NAS cytokine binding
GO:0021612 IEA facial nerve structural organization
GO:0021636 IEA trigeminal nerve morphogenesis
GO:0021637 IEA trigeminal nerve structural organization
GO:0021649 IEA vestibulocochlear nerve structural organization
GO:0021675 ISS nerve development
GO:0021785 IEA branchiomotor neuron axon guidance
GO:0021828 IEA gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0030424 ISS axon
GO:0030426 IEA growth cone
GO:0030517 IEA negative regulation of axon extension
GO:0031290 ISS retinal ganglion cell axon guidance
GO:0031410 TAS cytoplasmic vesicle
GO:0035729 IMP cellular response to hepatocyte growth factor stimulus
GO:0035767 IMP endothelial cell chemotaxis
GO:0035924 ISS cellular response to vascular endothelial growth factor stimulus
GO:0036486 IEA ventral trunk neural crest cell migration
GO:0038084 IEA vascular endothelial growth factor signaling pathway
GO:0038085 IPI vascular endothelial growth factor binding
GO:0038190 ISS VEGF-activated neuropilin signaling pathway
GO:0043025 IEA neuronal cell body
GO:0043049 IEA otic placode formation
GO:0043235 TAS receptor complex
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0046872 IEA metal ion binding
GO:0048008 IMP platelet-derived growth factor receptor signaling pathway
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048012 IMP hepatocyte growth factor receptor signaling pathway
GO:0048485 IEA sympathetic nervous system development
GO:0048666 IEA neuron development
GO:0048841 IEA regulation of axon extension involved in axon guidance
GO:0048842 ISS positive regulation of axon extension involved in axon guidance
GO:0048843 IEA negative regulation of axon extension involved in axon guidance
GO:0048844 ISS artery morphogenesis
GO:0048846 ISS axon extension involved in axon guidance
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 ISS positive chemotaxis
GO:0060301 TAS positive regulation of cytokine activity
GO:0060385 ISS axonogenesis involved in innervation
GO:0060627 TAS regulation of vesicle-mediated transport
GO:0060666 IEA dichotomous subdivision of terminal units involved in salivary gland branching
GO:0060978 ISS angiogenesis involved in coronary vascular morphogenesis
GO:0060982 IEA coronary artery morphogenesis
GO:0061299 ISS retina vasculature morphogenesis in camera-type eye
GO:0061441 IEA renal artery morphogenesis
GO:0061549 ISS sympathetic ganglion development
GO:0061551 IEA trigeminal ganglion development
GO:0061552 IEA ganglion morphogenesis
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071526 NAS semaphorin-plexin signaling pathway
GO:0071679 ISS commissural neuron axon guidance
GO:0090259 ISS regulation of retinal ganglion cell axon guidance
GO:0097102 ISS endothelial tip cell fate specification
GO:0097374 IEA sensory neuron axon guidance
GO:0097443 ISS sorting endosome
GO:0097490 ISS sympathetic neuron projection extension
GO:0097491 ISS sympathetic neuron projection guidance
GO:1901166 ISS neural crest cell migration involved in autonomic nervous system development
GO:1901998 IEA toxin transport
GO:1902285 ISS semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287 IEA semaphorin-plexin signaling pathway involved in axon guidance
GO:1902336 ISS positive regulation of retinal ganglion cell axon guidance
GO:1902378 IEA VEGF-activated neuropilin signaling pathway involved in axon guidance
GO:1902946 ISS protein localization to early endosome
GO:1903375 IEA facioacoustic ganglion development
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027290 nrp1b neuropilin 1b protein_coding Danio_rerio
ENSDARG00000071865 nrp1a neuropilin 1a protein_coding Danio_rerio
ENSMUSG00000025810 Nrp1 neuropilin 1 protein_coding Mus_musculus

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