C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101096 NFATC2 9606 - 20:51386957-51562831 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000371564 NFATC2-001 51386957-51542719 protein_coding
  ENST00000396009 NFATC2-002 51386957-51542719 protein_coding
  ENST00000414705 NFATC2-004 51391228-51562629 protein_coding
  ENST00000496054 NFATC2-003 51391409-51399219 retained_intron
  ENST00000609507 NFATC2-006 51391228-51562831 protein_coding
  ENST00000609943 NFATC2-005 51388626-51562831 protein_coding
  ENST00000610033 NFATC2-007 51391228-51542719 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000371564ENST00000396009ENST00000414705ENST00000609943
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000371564 0.259±0.00 0.956±0.00 N/A N/A N/A N/A N/A 0.063±0.00 N/A N/A 0.437±0.00 1.967±0.57 0.614±0.00
ENST00000396009 N/A N/A 0.473±0.00 0.508±0.00 0.245±0.00 N/A 0.658±0.00 N/A 1.003±0.51 N/A 0.569±0.19 0.732±0.00 0.211±0.00
ENST00000414705 N/A N/A 0.150±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000609943 N/A N/A N/A N/A 0.466±0.00 0.054±0.00 0.491±0.00 0.667±0.00 N/A 0.182±0.00 2.251±0.00 0.871±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000153 CIL_000153_0001 CGP 20:51003656-51562831
CIL_0007HZ CIL_0007HZ_0001 CGP 20:51386957-51768634

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001816 IEA cytokine production
GO:0003677 TAS DNA binding
GO:0003700 TAS:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 TAS:IEA regulation of transcription, DNA-templated
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0010628 IEA positive regulation of gene expression
GO:0015629 IDA actin cytoskeleton
GO:0016477 IDA cell migration
GO:0030529 IEA ribonucleoprotein complex
GO:0030890 IMP positive regulation of B cell proliferation
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042493 IMP response to drug
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0044798 IEA nuclear transcription factor complex
GO:0045087 TAS innate immune response
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0050853 IMP B cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076640 NFATC2 (1 of 2) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 protein_coding Danio_rerio
ENSDARG00000079972 CABZ01041608.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000027544 Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 protein_coding Mus_musculus

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