C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027544 Nfatc2 10090 - 2:168476410-168601657 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029057 Nfatc2-005 168519098-168590191 protein_coding
  ENSMUST00000074618 Nfatc2-002 168476410-168590260 protein_coding
  ENSMUST00000099067 Nfatc2-006 168518195-168601632 processed_transcript
  ENSMUST00000109184 Nfatc2-001 168476410-168590365 protein_coding
  ENSMUST00000137451 Nfatc2-004 168519098-168601657 protein_coding
  ENSMUST00000138546 Nfatc2-008 168566477-168590365 retained_intron
  ENSMUST00000140137 Nfatc2-007 168533463-168590331 retained_intron
  ENSMUST00000151292 Nfatc2-003 168476413-168552276 processed_transcript
  ENSMUST00000171689 Nfatc2-201 168518203-168601655 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029057ENSMUST00000074618ENSMUST00000099067ENSMUST00000109184ENSMUST00000137451ENSMUST00000138546ENSMUST00000151292
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029057 N/A N/A N/A 0.253±0.00 N/A N/A 1.975±0.33 N/A 0.061±0.00 N/A 1.225±0.00 0.345±0.00 0.278±0.00 0.388±0.24
ENSMUST00000074618 0.399±0.00 N/A 0.619±0.00 0.147±0.07 1.192±0.29 0.322±0.04 N/A 0.379±0.19 0.034±0.01 0.189±0.00 0.631±0.18 0.374±0.20 0.157±0.08 N/A
ENSMUST00000099067 N/A N/A N/A 0.612±0.50 N/A N/A N/A N/A N/A N/A N/A N/A 0.056±0.00 0.071±0.00
ENSMUST00000109184 0.544±0.23 0.960±0.25 0.131±0.00 N/A 2.777±1.50 0.868±0.21 1.090±0.30 0.488±0.12 0.031±0.01 0.510±0.11 1.149±0.59 0.587±0.19 0.178±0.11 N/A
ENSMUST00000137451 N/A N/A N/A 1.997±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000138546 N/A N/A N/A N/A N/A 0.656±0.00 N/A N/A N/A N/A N/A 0.341±0.02 N/A N/A
ENSMUST00000151292 0.286±0.00 N/A 0.615±0.10 0.458±0.09 0.679±0.00 0.945±0.32 0.814±0.24 0.550±0.12 0.038±0.01 N/A 1.555±0.00 0.483±0.22 0.255±0.19 0.291±0.19

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000153 CIL_000153_0002 CGP 2:168260117-168601657
CIL_0007HZ CIL_0007HZ_0002 CGP 2:168476410-168742409

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001816 IDA cytokine production
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IPI transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0010628 IMP positive regulation of gene expression
GO:0015629 IEA actin cytoskeleton
GO:0016477 ISS cell migration
GO:0030529 IDA ribonucleoprotein complex
GO:0030890 IEA positive regulation of B cell proliferation
GO:0042493 IEA response to drug
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044798 IDA nuclear transcription factor complex
GO:0045893 ISO positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050853 IEA B cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076640 NFATC2 (1 of 2) nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 protein_coding Danio_rerio
ENSDARG00000079972 CABZ01041608.1 Uncharacterized protein protein_coding Danio_rerio
ENSG00000101096 NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 protein_coding Homo_sapiens

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