C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: HCK proto-oncogene, Src family tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101336 HCK 9606 + 20:32052188-32101856 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262651 HCK-005 32052242-32101849 nonsense_mediated_decay
  ENST00000375852 HCK-001 32052261-32101856 protein_coding
  ENST00000375862 HCK-002 32052197-32101519 protein_coding
  ENST00000470092 HCK-003 32052288-32072589 retained_intron
  ENST00000486475 HCK-004 32052242-32101660 nonsense_mediated_decay
  ENST00000518730 HCK-007 32052261-32101519 protein_coding
  ENST00000520553 HCK-006 32052242-32101856 protein_coding
  ENST00000534862 HCK-201 32052188-32101852 protein_coding
  ENST00000538448 HCK-202 32052188-32101852 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262651ENST00000375852ENST00000375862ENST00000486475ENST00000518730ENST00000520553ENST00000534862
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262651 N/A N/A N/A 0.747±0.00 0.540±0.00 N/A 0.077±0.00 N/A 0.413±0.00 N/A N/A N/A N/A 0.682±0.00
ENST00000375852 N/A N/A N/A N/A 1.980±0.00 0.771±0.00 3.728±0.00 0.329±0.00 1.519±0.00 2.761±0.00 0.461±0.00 0.880±0.49 9.594±5.52 N/A
ENST00000375862 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.178±0.00
ENST00000486475 3.242±0.00 8.360±0.00 N/A 2.279±0.00 2.449±0.00 0.756±0.00 N/A N/A N/A 4.946±0.00 N/A N/A N/A 0.702±0.00
ENST00000518730 N/A N/A 0.117±0.00 1.967±0.00 N/A 1.030±0.00 N/A 2.853±0.00 1.039±0.00 3.612±1.13 N/A 1.350±0.32 3.651±0.00 0.807±0.00
ENST00000520553 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.864±0.00 10.484±7.39 N/A
ENST00000534862 4.269±0.00 14.502±0.00 N/A 1.914±0.67 1.775±0.00 0.753±0.00 0.381±0.00 0.869±0.00 1.493±0.00 16.464±0.00 N/A 4.157±0.00 3.029±0.00 1.757±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004A2 CIL_0004A2_0001 CGP 20:32010450-32101856
CIL_00071A CIL_00071A_0002 CGP 20:32052188-32167258

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002522 TAS leukocyte migration involved in immune response
GO:0002758 TAS innate immune response-activating signal transduction
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005764 IDA lysosome
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005884 IDA actin filament
GO:0005901 IDA caveola
GO:0005925 IMP focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0006909 IEA phagocytosis
GO:0006954 IEA inflammatory response
GO:0007155 TAS cell adhesion
GO:0007229 TAS integrin-mediated signaling pathway
GO:0007498 TAS mesoderm development
GO:0008284 IMP positive regulation of cell proliferation
GO:0008360 IMP regulation of cell shape
GO:0016032 TAS viral process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0030838 TAS positive regulation of actin filament polymerization
GO:0031234 IMP extrinsic component of cytoplasmic side of plasma membrane
GO:0031410 IEA cytoplasmic vesicle
GO:0031663 TAS lipopolysaccharide-mediated signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042995 IEA cell projection
GO:0043066 IMP negative regulation of apoptotic process
GO:0043299 TAS leukocyte degranulation
GO:0045087 TAS innate immune response
GO:0045728 TAS respiratory burst after phagocytosis
GO:0046777 IMP protein autophosphorylation
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050727 TAS regulation of inflammatory response
GO:0050764 IMP regulation of phagocytosis
GO:0050830 IEA defense response to Gram-positive bacterium
GO:0051090 IMP regulation of sequence-specific DNA binding transcription factor activity
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0071801 IDA regulation of podosome assembly
GO:2000251 IMP positive regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058647 hck hemopoietic cell kinase protein_coding Danio_rerio
ENSMUSG00000003283 Hck hemopoietic cell kinase protein_coding Mus_musculus

Loading