C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: HCK proto-oncogene, Src family tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000518730 HCK-007 ENSG00000101336 9606 + 20:32052261-32101519 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainColonKidneyLiverLungOvaryPlacentaTestisENST00000518730
Transcript ID Bladder Brain Colon Kidney Liver Lung Ovary Placenta Testis
ENST00000518730 0.117±0.00 1.967±0.00 1.030±0.00 2.853±0.00 1.039±0.00 3.612±1.13 1.350±0.32 3.651±0.00 0.807±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004A2 CIL_0004A2_0001 CGP 20:32010450-32101856
CIL_00071A CIL_00071A_0002 CGP 20:32052188-32167258

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002522 TAS leukocyte migration involved in immune response
GO:0002758 TAS innate immune response-activating signal transduction
GO:0004672 IEA protein kinase activity
GO:0004713 IMP:IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005764 IDA lysosome
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005884 IDA actin filament
GO:0005901 IDA caveola
GO:0005925 IMP focal adhesion
GO:0006468 TAS:IEA protein phosphorylation
GO:0006954 IEA inflammatory response
GO:0007155 TAS cell adhesion
GO:0007229 TAS integrin-mediated signaling pathway
GO:0007498 TAS mesoderm development
GO:0008284 IMP positive regulation of cell proliferation
GO:0008360 IMP regulation of cell shape
GO:0016032 TAS viral process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IMP peptidyl-tyrosine phosphorylation
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0030838 TAS positive regulation of actin filament polymerization
GO:0031234 IMP extrinsic component of cytoplasmic side of plasma membrane
GO:0031410 IEA cytoplasmic vesicle
GO:0031663 TAS lipopolysaccharide-mediated signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042995 IEA cell projection
GO:0043066 IMP negative regulation of apoptotic process
GO:0043299 TAS leukocyte degranulation
GO:0045087 TAS innate immune response
GO:0045728 TAS respiratory burst after phagocytosis
GO:0046777 IMP protein autophosphorylation
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050727 TAS regulation of inflammatory response
GO:0050764 IMP regulation of phagocytosis
GO:0051090 IMP regulation of sequence-specific DNA binding transcription factor activity
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0071801 IDA regulation of podosome assembly
GO:2000251 IMP positive regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000189688 Hck-201 protein_coding Mus_musculus 0 1757
ENSMUST00000191431 Hck-202 protein_coding Mus_musculus 0 1757
ENSMUST00000003370 Hck-002 protein_coding Mus_musculus 0 1757
ENSMUST00000109799 Hck-001 protein_coding Mus_musculus 0 1757

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