C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101843 PSMD10 9606 - X:108084207-108091618 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000217958 PSMD10-001 108084207-108091618 protein_coding
  ENST00000338548 PSMD10-003 108088480-108091549 retained_intron
  ENST00000340200 PSMD10-006 108084843-108091520 protein_coding
  ENST00000361815 PSMD10-002 108084830-108091542 protein_coding
  ENST00000372295 PSMD10-004 108084775-108091542 protein_coding
  ENST00000372296 PSMD10-005 108084597-108091542 protein_coding
  ENST00000553388 PSMD10-007 108087045-108091538 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000217958ENST00000338548ENST00000340200ENST00000361815ENST00000372295ENST00000372296
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000217958 4.943±0.00 7.194±0.00 1.207±0.00 13.280±3.51 6.516±1.41 6.982±2.86 1.873±0.55 5.265±2.47 3.864±1.88 6.882±4.38 1.822±0.06 11.710±4.89 11.647±3.35 10.590±7.25
ENST00000338548 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.632±0.00 6.845±0.00 3.773±0.00
ENST00000340200 5.619±0.00 4.836±0.00 3.994±0.00 6.123±0.00 5.925±0.13 4.464±0.00 0.672±0.00 0.931±0.00 3.527±0.00 6.580±0.00 2.069±1.02 2.564±0.00 N/A 6.528±0.00
ENST00000361815 N/A N/A 2.089±0.00 7.889±1.76 N/A 1.627±0.00 0.614±0.00 N/A N/A N/A N/A 5.192±0.00 N/A N/A
ENST00000372295 N/A N/A N/A N/A N/A N/A 1.180±0.23 N/A N/A 4.167±2.45 N/A N/A N/A N/A
ENST00000372296 3.269±0.00 6.346±0.00 N/A 8.299±0.00 5.281±0.00 9.446±0.00 1.457±0.00 6.698±0.00 3.514±0.00 6.327±0.00 1.006±0.00 1.641±0.00 1.681±0.00 4.812±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006JJ CIL_0006JJ_0001 CGP X:108044970-108091618
CIL_0006JI CIL_0006JI_0001 CGP X:108084207-108154671

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005838 TAS proteasome regulatory particle
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007253 IDA cytoplasmic sequestering of NF-kappaB
GO:0008134 IPI transcription factor binding
GO:0008540 IDA proteasome regulatory particle, base subcomplex
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0030307 IDA positive regulation of cell growth
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 IMP positive regulation of protein ubiquitination
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0032436 TAS positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043409 IMP negative regulation of MAPK cascade
GO:0043518 IDA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044281 TAS small molecule metabolic process
GO:0045111 IDA intermediate filament cytoskeleton
GO:0045737 IDA positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070682 IMP proteasome regulatory particle assembly
GO:0090201 IMP negative regulation of release of cytochrome c from mitochondria

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015628 psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 protein_coding Danio_rerio
ENSMUSG00000031429 Psmd10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 protein_coding Mus_musculus

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