C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DENN/MADD domain containing 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105339 DENND3 9606 + 8:141117278-141195808 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262585 DENND3-201 141128621-141195796 protein_coding
  ENST00000424248 DENND3-202 141136626-141195511 protein_coding
  ENST00000517813 DENND3-006 141184488-141195807 retained_intron
  ENST00000517985 DENND3-015 141178121-141185458 protein_coding
  ENST00000518198 DENND3-003 141128621-141142511 nonsense_mediated_decay
  ENST00000518249 DENND3-016 141141203-141143008 protein_coding
  ENST00000518347 DENND3-011 141128612-141141455 protein_coding
  ENST00000518668 DENND3-002 141128779-141195808 protein_coding
  ENST00000518806 DENND3-020 141177087-141185223 processed_transcript
  ENST00000519291 DENND3-010 141117278-141141276 protein_coding
  ENST00000519811 DENND3-001 141128638-141195808 protein_coding
  ENST00000520482 DENND3-005 141157395-141176266 retained_intron
  ENST00000520571 DENND3-009 141188898-141190624 retained_intron
  ENST00000520725 DENND3-014 141192331-141193070 protein_coding
  ENST00000520986 DENND3-012 141128649-141151837 protein_coding
  ENST00000521477 DENND3-018 141155894-141166233 processed_transcript
  ENST00000521835 DENND3-008 141191274-141195799 retained_intron
  ENST00000523015 DENND3-017 141143914-141150889 retained_intron
  ENST00000523058 DENND3-021 141128675-141150908 protein_coding
  ENST00000523066 DENND3-019 141173505-141176652 processed_transcript
  ENST00000523308 DENND3-007 141188349-141195802 protein_coding
  ENST00000523530 DENND3-013 141191274-141192901 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262585ENST00000424248ENST00000517813ENST00000517985ENST00000518668ENST00000518806ENST00000519811ENST00000520482ENST00000521835ENST00000523308
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262585 5.772±0.00 N/A N/A 1.492±0.00 1.927±0.00 1.355±0.00 3.179±0.00 4.155±0.00 0.586±0.00 7.439±0.00 0.439±0.00 1.075±0.06 3.650±0.00 1.714±0.00
ENST00000424248 6.556±0.00 4.447±0.00 N/A 2.207±0.00 1.860±0.00 1.054±0.35 N/A 1.097±0.82 N/A 5.546±0.00 N/A 2.172±0.00 1.843±0.87 N/A
ENST00000517813 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.106±0.00 N/A N/A
ENST00000517985 N/A N/A N/A N/A N/A N/A N/A 1.356±0.00 N/A N/A N/A N/A N/A N/A
ENST00000518668 N/A N/A N/A N/A N/A N/A N/A N/A 0.181±0.00 N/A 0.463±0.00 1.460±0.00 1.285±0.04 N/A
ENST00000518806 N/A N/A N/A N/A 2.967±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000519811 2.543±0.00 N/A N/A 1.581±0.00 1.208±0.00 1.628±1.07 2.014±0.00 N/A N/A 4.568±1.48 0.461±0.00 1.015±0.12 1.784±0.48 N/A
ENST00000520482 N/A N/A N/A N/A 2.525±0.00 1.159±0.00 N/A 0.704±0.00 0.787±0.00 5.392±0.00 0.423±0.00 N/A N/A N/A
ENST00000521835 N/A N/A 1.283±0.00 N/A N/A N/A N/A N/A N/A N/A 0.385±0.00 N/A N/A 1.969±0.00
ENST00000523308 N/A 4.876±0.00 N/A N/A N/A 0.983±0.00 N/A N/A 1.006±0.00 N/A 0.385±0.00 2.665±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006FQ CIL_0006FQ_0002 CGP 8:140657900-141195808
CIL_0007WG CIL_0007WG_0001 VISTA 8:141111247-141716252
CIL_0000X9 CIL_0000X9_0002 CGP 8:141117278-141308305

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IEA protein binding
GO:0008333 ISS endosome to lysosome transport
GO:0017112 IDA Rab guanyl-nucleotide exchange factor activity
GO:0032851 IDA positive regulation of Rab GTPase activity
GO:0044257 ISS cellular protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013153 dennd3b DENN/MADD domain containing 3b protein_coding Danio_rerio
ENSDARG00000078797 dennd3a DENN/MADD domain containing 3a protein_coding Danio_rerio
ENSMUSG00000036661 Dennd3 DENN/MADD domain containing 3 protein_coding Mus_musculus

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