C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: enhancer of zeste 2 polycomb repressive complex 2 subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106462 EZH2 9606 - 7:148807383-148884321 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000320356 EZH2-004 148807385-148884278 protein_coding
  ENST00000350995 EZH2-010 148807385-148884248 protein_coding
  ENST00000460911 EZH2-008 148807385-148884245 protein_coding
  ENST00000469631 EZH2-009 148810200-148811823 retained_intron
  ENST00000476773 EZH2-007 148807482-148883509 protein_coding
  ENST00000478654 EZH2-006 148807384-148884159 protein_coding
  ENST00000483012 EZH2-005 148818037-148884321 nonsense_mediated_decay
  ENST00000483967 EZH2-001 148807525-148884287 protein_coding
  ENST00000492143 EZH2-003 148807383-148884283 nonsense_mediated_decay
  ENST00000498186 EZH2-002 148817357-148884287 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000350995ENST00000460911ENST00000469631ENST00000476773ENST00000483012ENST00000483967ENST00000492143ENST00000498186
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000350995 N/A N/A N/A 0.236±0.00 0.232±0.00 0.051±0.00 N/A N/A N/A 0.411±0.00 0.518±0.00 2.380±0.00 0.877±0.12 N/A
ENST00000460911 0.552±0.00 0.921±0.00 N/A N/A N/A N/A 0.141±0.00 N/A 0.184±0.00 N/A N/A 1.943±1.63 1.760±0.53 8.585±0.00
ENST00000469631 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.172±0.00 N/A N/A N/A
ENST00000476773 N/A N/A N/A 0.015±0.00 N/A 0.342±0.00 N/A N/A N/A N/A N/A N/A N/A 2.870±0.00
ENST00000483012 N/A N/A 0.430±0.00 0.148±0.00 N/A N/A 0.034±0.00 0.720±0.00 N/A 0.748±0.00 N/A 5.815±4.25 3.952±0.00 29.946±0.00
ENST00000483967 0.232±0.00 N/A N/A N/A 0.162±0.00 N/A N/A N/A 0.289±0.00 N/A N/A 2.798±2.93 2.209±0.00 13.690±8.47
ENST00000492143 0.085±0.00 N/A 0.121±0.00 N/A 0.769±0.00 N/A N/A 0.172±0.00 N/A N/A N/A 0.727±0.37 N/A N/A
ENST00000498186 N/A N/A N/A N/A 0.717±0.00 0.645±0.00 0.023±0.00 0.099±0.00 0.217±0.00 N/A N/A 1.190±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004XU CIL_0004XU_0001 CGP 7:148697914-148884321
CIL_0004XT CIL_0004XT_0001 CGP 7:148807383-149028641

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000790 IDA nuclear chromatin
GO:0000975 IEA regulatory region DNA binding
GO:0001047 ISS core promoter binding
GO:0001932 IEA regulation of protein phosphorylation
GO:0003677 TAS:IEA DNA binding
GO:0003682 IDA:IEA chromatin binding
GO:0003723 IEA RNA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006306 IEA DNA methylation
GO:0006325 TAS chromatin organization
GO:0006351 IEA transcription, DNA-templated
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0010468 IEA regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010718 IDA positive regulation of epithelial to mesenchymal transition
GO:0014013 IEA regulation of gliogenesis
GO:0014834 IEA skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0016571 IEA histone methylation
GO:0018024 IEA histone-lysine N-methyltransferase activity
GO:0021695 IEA cerebellar cortex development
GO:0031490 IDA chromatin DNA binding
GO:0032320 IDA positive regulation of Ras GTPase activity
GO:0034244 IEA negative regulation of transcription elongation from RNA polymerase II promoter
GO:0034968 IEA histone lysine methylation
GO:0035098 IDA ESC/E(Z) complex
GO:0042054 IDA histone methyltransferase activity
GO:0042127 IEA regulation of cell proliferation
GO:0042752 IMP regulation of circadian rhythm
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043565 IEA sequence-specific DNA binding
GO:0045120 IEA pronucleus
GO:0045605 IEA negative regulation of epidermal cell differentiation
GO:0045814 IDA negative regulation of gene expression, epigenetic
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0046976 TAS histone methyltransferase activity (H3-K27 specific)
GO:0048387 IMP negative regulation of retinoic acid receptor signaling pathway
GO:0050767 IEA regulation of neurogenesis
GO:0051154 IEA negative regulation of striated muscle cell differentiation
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0070314 IEA G1 to G0 transition
GO:0070734 IDA histone H3-K27 methylation
GO:0071168 IEA protein localization to chromatin
GO:0071902 IDA positive regulation of protein serine/threonine kinase activity
GO:2000134 IEA negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010571 ezh2 enhancer of zeste homolog 2 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000029687 Ezh2 enhancer of zeste homolog 2 (Drosophila) protein_coding Mus_musculus

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