C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dedicator of cytokinesis 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000107099 DOCK8 9606 + 9:214854-465259 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000382329 DOCK8-005 366251-465255 protein_coding
  ENST00000382331 DOCK8-009 366229-405099 protein_coding
  ENST00000382341 DOCK8-002 273050-340620 retained_intron
  ENST00000432829 DOCK8-001 214865-465259 protein_coding
  ENST00000453981 DOCK8-201 273048-465259 protein_coding
  ENST00000454469 DOCK8-010 214868-340620 retained_intron
  ENST00000462618 DOCK8-016 463555-465247 processed_transcript
  ENST00000469197 DOCK8-008 214854-286636 nonsense_mediated_decay
  ENST00000469391 DOCK8-012 273070-464526 protein_coding
  ENST00000474772 DOCK8-007 311958-314466 processed_transcript
  ENST00000478380 DOCK8-011 273066-312941 retained_intron
  ENST00000479404 DOCK8-013 215171-289579 protein_coding
  ENST00000483757 DOCK8-004 273059-381387 nonsense_mediated_decay
  ENST00000487230 DOCK8-014 273050-304703 protein_coding
  ENST00000493666 DOCK8-015 420116-426953 processed_transcript
  ENST00000495184 DOCK8-006 273084-465241 retained_intron
  ENST00000524396 DOCK8-018 214865-340620 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000382329ENST00000382331ENST00000382341ENST00000432829ENST00000453981ENST00000454469ENST00000462618ENST00000469197ENST00000469391ENST00000474772ENST00000495184
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000382329 N/A N/A N/A 0.290±0.00 N/A 1.037±0.00 N/A 2.158±0.00 N/A N/A N/A 1.020±0.42 1.090±0.18 3.151±0.00
ENST00000382331 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.500±0.00 N/A N/A N/A
ENST00000382341 N/A N/A N/A N/A N/A 1.809±0.00 N/A N/A N/A 4.165±0.00 N/A N/A N/A N/A
ENST00000432829 2.028±0.00 2.219±0.00 1.609±0.00 0.506±0.10 1.760±0.00 N/A 0.512±0.00 1.445±0.67 0.526±0.29 1.079±0.00 0.170±0.00 0.809±0.30 4.030±0.35 0.710±0.00
ENST00000453981 N/A 3.167±0.00 N/A N/A N/A N/A N/A N/A N/A 0.667±0.00 N/A 0.533±0.00 0.812±0.00 N/A
ENST00000454469 N/A N/A N/A N/A N/A N/A N/A 2.099±0.00 1.603±0.00 N/A N/A N/A N/A N/A
ENST00000462618 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.545±0.00 N/A N/A
ENST00000469197 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.383±0.00 N/A N/A N/A
ENST00000469391 N/A N/A N/A N/A 0.968±0.00 0.606±0.00 0.127±0.00 N/A 0.374±0.00 N/A N/A N/A 3.524±0.00 1.458±0.61
ENST00000474772 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 23.180±0.00
ENST00000495184 N/A N/A 0.535±0.00 N/A 1.388±0.00 0.658±0.45 N/A N/A 0.186±0.00 1.549±0.00 0.153±0.00 0.381±0.00 N/A 1.175±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009AF CIL_0009AF_0001 VISTA 9:-140343-460780
CIL_0000VS CIL_0000VS_0001 CGP 9:214854-746106

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001771 IEA immunological synapse formation
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007596 TAS blood coagulation
GO:0016020 IDA membrane
GO:0031252 IEA cell leading edge
GO:0036336 IEA dendritic cell migration
GO:0043547 IEA positive regulation of GTPase activity
GO:0061485 IMP memory T cell proliferation
GO:0070233 IEA negative regulation of T cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055225 dock8 dedicator of cytokinesis 8 protein_coding Danio_rerio
ENSMUSG00000052085 Dock8 dedicator of cytokinesis 8 protein_coding Mus_musculus

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