C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dedicator of cytokinesis 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000052085 Dock8 10090 + 19:24999529-25202432 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025831 Dock8-201 24999529-25202432 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025831
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025831 3.484±1.14 5.628±1.07 14.093±3.85 0.279±0.31 8.650±3.70 4.431±0.53 0.782±0.30 7.678±1.68 2.673±1.74 13.101±0.36 0.378±0.18 8.357±1.49 5.880±4.57 1.323±0.28

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009AF CIL_0009AF_0002 VISTA 19:24645396-25246544
CIL_0000VS CIL_0000VS_0002 CGP 19:24999529-25434496

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001771 IMP immunological synapse formation
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0007264 IEA small GTPase mediated signal transduction
GO:0016020 IEA membrane
GO:0031252 IDA cell leading edge
GO:0036336 IGI dendritic cell migration
GO:0043547 IEA positive regulation of GTPase activity
GO:0061485 IEA memory T cell proliferation
GO:0070233 IMP negative regulation of T cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055225 dock8 dedicator of cytokinesis 8 protein_coding Danio_rerio
ENSG00000107099 DOCK8 dedicator of cytokinesis 8 protein_coding Homo_sapiens

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