C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, cAMP-dependent, regulatory, type I, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108946 PRKAR1A 9606 + 17:68511780-68551319 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000358598 PRKAR1A-004 68512032-68532762 protein_coding
  ENST00000392710 PRKAR1A-003 68512450-68532759 nonsense_mediated_decay
  ENST00000392711 PRKAR1A-201 68512379-68533423 protein_coding
  ENST00000536854 PRKAR1A-002 68512450-68532762 protein_coding
  ENST00000585427 PRKAR1A-010 68512416-68524046 protein_coding
  ENST00000585460 PRKAR1A-018 68512430-68524130 retained_intron
  ENST00000585608 PRKAR1A-017 68512426-68525912 nonsense_mediated_decay
  ENST00000585815 PRKAR1A-015 68512921-68522774 protein_coding
  ENST00000585907 PRKAR1A-007 68527584-68530319 retained_intron
  ENST00000585981 PRKAR1A-013 68512882-68528992 protein_coding
  ENST00000586397 PRKAR1A-005 68514821-68530664 protein_coding
  ENST00000586541 PRKAR1A-020 68525882-68530461 nonsense_mediated_decay
  ENST00000588178 PRKAR1A-016 68515123-68524956 protein_coding
  ENST00000588188 PRKAR1A-006 68515400-68551319 protein_coding
  ENST00000588702 PRKAR1A-011 68512467-68524078 protein_coding
  ENST00000589017 PRKAR1A-008 68511780-68525818 protein_coding
  ENST00000589228 PRKAR1A-001 68512427-68533431 protein_coding
  ENST00000589309 PRKAR1A-012 68512487-68515536 protein_coding
  ENST00000589480 PRKAR1A-014 68512900-68522917 protein_coding
  ENST00000592194 PRKAR1A-009 68512415-68515815 retained_intron
  ENST00000592800 PRKAR1A-019 68525795-68530654 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000358598ENST00000392710ENST00000536854ENST00000585981ENST00000589228ENST00000592800
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000358598 36.475±0.00 20.576±0.00 34.511±0.00 67.067±3.24 24.211±3.95 33.175±4.73 64.369±19.36 32.941±11.79 17.794±5.13 39.109±23.62 55.394±48.40 52.957±9.81 28.746±0.95 50.497±0.00
ENST00000392710 117.513±0.00 32.616±0.00 10.425±0.00 36.545±16.25 61.621±0.00 43.605±0.00 30.283±6.64 22.875±15.78 10.142±1.81 26.879±5.28 42.885±0.00 20.765±3.57 21.038±8.31 39.059±18.53
ENST00000536854 N/A N/A N/A N/A 20.820±0.00 N/A N/A N/A 43.991±0.00 31.396±0.00 N/A N/A N/A N/A
ENST00000585981 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 37.534±0.00 66.251±0.00 133.844±0.00
ENST00000589228 N/A N/A N/A 18.356±0.00 N/A N/A N/A N/A N/A 13.373±0.00 7.977±0.00 13.072±0.00 N/A N/A
ENST00000592800 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 47.659±0.00 73.238±0.00 133.336±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006GP CIL_0006GP_0001 CGP 17:68420948-68551319
CIL_0003AG CIL_0003AG_0002 CGP 17:68511780-68601389

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001707 IEA mesoderm formation
GO:0001932 IEA regulation of protein phosphorylation
GO:0004862 IDA cAMP-dependent protein kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0006112 TAS energy reserve metabolic process
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006833 TAS water transport
GO:0007143 IEA female meiotic division
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007507 IEA heart development
GO:0007596 TAS blood coagulation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008603 IDA:IEA cAMP-dependent protein kinase regulator activity
GO:0016020 IDA membrane
GO:0030552 IEA cAMP binding
GO:0031588 IDA AMP-activated protein kinase complex
GO:0031594 IEA neuromuscular junction
GO:0031625 IDA ubiquitin protein ligase binding
GO:0034199 TAS activation of protein kinase A activity
GO:0034236 IPI protein kinase A catalytic subunit binding
GO:0035556 TAS intracellular signal transduction
GO:0043234 IDA protein complex
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045214 IEA sarcomere organization
GO:0045835 IEA negative regulation of meiosis
GO:0045859 IEA regulation of protein kinase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050796 TAS regulation of insulin secretion
GO:0055085 TAS transmembrane transport
GO:0060038 IEA cardiac muscle cell proliferation
GO:0071377 TAS cellular response to glucagon stimulus
GO:2000480 IDA negative regulation of cAMP-dependent protein kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012094 prkar1ab protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b protein_coding Danio_rerio
ENSDARG00000076128 prkar1aa protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a protein_coding Danio_rerio
ENSMUSG00000020612 Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha protein_coding Mus_musculus

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