C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, cAMP dependent regulatory, type I, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020612 Prkar1a 10090 + 11:109649405-109669656 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000049527 Prkar1a-001 109650921-109669656 protein_coding
  ENSMUST00000106676 Prkar1a-004 109650575-109661753 protein_coding
  ENSMUST00000106677 Prkar1a-002 109649405-109669656 protein_coding
  ENSMUST00000123354 Prkar1a-003 109649405-109653961 processed_transcript
  ENSMUST00000155532 Prkar1a-005 109665944-109666976 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000049527ENSMUST00000106677
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000049527 54.070±17.60 209.442±10.25 77.576±9.17 83.003±5.48 73.579±29.13 52.130±8.60 70.242±7.16 63.574±4.25 42.792±3.63 104.368±7.67 19.171±2.06 100.313±17.57 37.177±9.38 38.296±6.66
ENSMUST00000106677 11.878±0.00 N/A 11.007±0.00 28.087±17.72 N/A N/A 25.430±3.25 N/A N/A N/A 10.027±1.90 15.657±4.85 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006GP CIL_0006GP_0002 CGP 11:109573331-109669656
CIL_0003AG CIL_0003AG_0003 CGP 11:109649405-109722279

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001707 IMP mesoderm formation
GO:0004862 IEA cAMP-dependent protein kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005737 TAS cytoplasm
GO:0005886 IEA plasma membrane
GO:0006468 TAS protein phosphorylation
GO:0006469 IMP negative regulation of protein kinase activity
GO:0007143 IEA female meiotic division
GO:0007507 IMP heart development
GO:0008283 TAS cell proliferation
GO:0008603 IGI cAMP-dependent protein kinase regulator activity
GO:0009887 TAS organ morphogenesis
GO:0016020 IEA membrane
GO:0030552 IEA cAMP binding
GO:0031588 IEA AMP-activated protein kinase complex
GO:0031594 IDA neuromuscular junction
GO:0031625 IEA ubiquitin protein ligase binding
GO:0034236 IEA protein kinase A catalytic subunit binding
GO:0043234 IEA protein complex
GO:0045214 IMP sarcomere organization
GO:0045835 IEA negative regulation of meiosis
GO:0045859 IEA regulation of protein kinase activity
GO:0060038 IMP cardiac muscle cell proliferation
GO:2000480 IEA negative regulation of cAMP-dependent protein kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012094 prkar1ab protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b protein_coding Danio_rerio
ENSDARG00000076128 prkar1aa protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a protein_coding Danio_rerio
ENSG00000108946 PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha protein_coding Homo_sapiens

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