C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: general transcription factor IIH, polypeptide 1, 62kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000110768 GTF2H1 9606 + 11:18322295-18367044 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265963 GTF2H1-001 18322596-18367044 protein_coding
  ENST00000418116 GTF2H1-017 18322557-18360770 retained_intron
  ENST00000453096 GTF2H1-002 18322295-18366261 protein_coding
  ENST00000524753 GTF2H1-014 18338217-18348831 protein_coding
  ENST00000525831 GTF2H1-006 18322569-18335884 protein_coding
  ENST00000526282 GTF2H1-013 18352098-18358642 retained_intron
  ENST00000526461 GTF2H1-007 18322568-18333454 retained_intron
  ENST00000526630 GTF2H1-011 18351572-18365898 protein_coding
  ENST00000528427 GTF2H1-012 18352018-18358102 retained_intron
  ENST00000530496 GTF2H1-010 18347104-18366275 protein_coding
  ENST00000531757 GTF2H1-004 18322547-18335904 processed_transcript
  ENST00000532227 GTF2H1-008 18322582-18333609 retained_intron
  ENST00000534213 GTF2H1-005 18322567-18333183 processed_transcript
  ENST00000534641 GTF2H1-003 18322567-18366813 protein_coding
  ENST00000543932 GTF2H1-018 18332662-18341608 retained_intron
  ENST00000607664 GTF2H1-019 18341409-18341958 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265963ENST00000418116ENST00000453096ENST00000524753ENST00000534641ENST00000607664
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265963 2.241±0.00 3.096±0.00 N/A 4.000±1.52 3.008±1.46 3.139±0.00 1.628±1.08 3.434±2.61 2.224±0.46 0.682±0.00 1.045±0.00 4.527±2.40 2.664±0.58 6.054±2.16
ENST00000418116 N/A N/A 1.000±0.00 2.941±0.00 5.532±0.00 3.329±0.00 2.096±0.00 2.855±0.00 5.001±0.00 4.780±0.00 1.643±0.00 5.520±0.00 N/A N/A
ENST00000453096 N/A 1.449±0.00 0.553±0.00 N/A N/A N/A 1.774±0.00 1.473±0.00 N/A 1.086±0.00 N/A N/A 3.054±0.00 4.168±0.00
ENST00000524753 N/A N/A N/A 2.934±0.00 N/A N/A N/A N/A N/A 2.422±0.00 N/A N/A N/A N/A
ENST00000534641 2.698±0.00 2.236±0.00 N/A 3.302±0.00 2.538±0.00 2.081±0.00 1.510±0.75 2.419±0.00 1.974±0.00 2.267±0.00 2.486±0.00 4.997±2.28 3.211±0.84 11.225±5.19
ENST00000607664 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.225±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00041D CIL_00041D_0002 CGP 11:18278668-18367044
CIL_000445 CIL_000445_0001 CGP 11:18322295-18408425

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000079 TAS regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000439 IEA core TFIIH complex
GO:0000718 TAS nucleotide-excision repair, DNA damage removal
GO:0004672 IDA protein kinase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005675 IDA holo TFIIH complex
GO:0006200 IDA ATP catabolic process
GO:0006281 TAS DNA repair
GO:0006283 TAS transcription-coupled nucleotide-excision repair
GO:0006289 IEA:TAS nucleotide-excision repair
GO:0006351 IEA transcription, DNA-templated
GO:0006360 TAS transcription from RNA polymerase I promoter
GO:0006361 TAS transcription initiation from RNA polymerase I promoter
GO:0006362 TAS transcription elongation from RNA polymerase I promoter
GO:0006363 TAS termination of RNA polymerase I transcription
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006368 TAS transcription elongation from RNA polymerase II promoter
GO:0006370 TAS 7-methylguanosine mRNA capping
GO:0006468 IDA protein phosphorylation
GO:0008094 IDA DNA-dependent ATPase activity
GO:0008353 IDA RNA polymerase II carboxy-terminal domain kinase activity
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050434 TAS positive regulation of viral transcription

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026701 gtf2h1 general transcription factor II H, polypeptide 1 protein_coding Danio_rerio
ENSDARG00000095079 gtf2h1 general transcription factor II H, polypeptide 1 protein_coding Danio_rerio
ENSMUSG00000006599 Gtf2h1 general transcription factor II H, polypeptide 1 protein_coding Mus_musculus

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