C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000110911 SLC11A2 9606 - 12:50979401-51028566 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262051 SLC11A2-006 50979535-51026359 protein_coding
  ENST00000262052 SLC11A2-002 50985992-51026384 protein_coding
  ENST00000394904 SLC11A2-201 50985992-51028275 protein_coding
  ENST00000541174 SLC11A2-005 50987946-51026141 protein_coding
  ENST00000545993 SLC11A2-008 50988173-51009249 protein_coding
  ENST00000546488 SLC11A2-012 50996941-51026384 protein_coding
  ENST00000546636 SLC11A2-004 50979820-51026368 nonsense_mediated_decay
  ENST00000546743 SLC11A2-003 50988320-51026400 protein_coding
  ENST00000547198 SLC11A2-007 50981009-51026338 protein_coding
  ENST00000547510 SLC11A2-015 50996871-51026393 nonsense_mediated_decay
  ENST00000547579 SLC11A2-010 50996961-51026391 protein_coding
  ENST00000547688 SLC11A2-001 50987939-51028566 protein_coding
  ENST00000547732 SLC11A2-014 51000318-51026363 protein_coding
  ENST00000548150 SLC11A2-025 51010720-51024843 protein_coding
  ENST00000548193 SLC11A2-020 51000402-51026384 protein_coding
  ENST00000548554 SLC11A2-023 50990584-50991667 retained_intron
  ENST00000549110 SLC11A2-017 51000350-51005848 protein_coding
  ENST00000549193 SLC11A2-016 51005322-51009168 processed_transcript
  ENST00000549625 SLC11A2-018 51005319-51026384 nonsense_mediated_decay
  ENST00000550061 SLC11A2-021 50995684-50999565 retained_intron
  ENST00000550329 SLC11A2-019 51008145-51026379 retained_intron
  ENST00000550714 SLC11A2-011 50999368-51026384 protein_coding
  ENST00000550782 SLC11A2-009 50985993-50995092 retained_intron
  ENST00000550995 SLC11A2-013 51005404-51026365 processed_transcript
  ENST00000551215 SLC11A2-024 50979401-50992209 nonsense_mediated_decay
  ENST00000551231 SLC11A2-022 50991599-50993144 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262051ENST00000262052ENST00000545993ENST00000546636ENST00000546743ENST00000547198ENST00000549110ENST00000550782
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262051 1.572±0.00 3.426±0.00 N/A 2.392±0.00 1.650±0.00 1.226±0.00 2.278±1.18 0.779±0.00 2.400±0.00 1.354±0.00 3.520±0.75 2.797±0.59 2.040±0.34
ENST00000262052 N/A N/A 12.629±0.00 N/A N/A 0.533±0.00 N/A 2.934±0.00 3.830±0.00 0.860±0.00 2.389±1.01 3.091±1.50 N/A
ENST00000545993 N/A N/A N/A 3.470±0.00 N/A N/A 3.009±0.00 N/A N/A N/A 3.361±0.00 N/A N/A
ENST00000546636 N/A N/A N/A N/A 2.418±0.00 1.464±0.00 N/A N/A N/A 1.475±0.00 N/A 3.638±0.00 N/A
ENST00000546743 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.780±0.00
ENST00000547198 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.343±0.00
ENST00000549110 N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.717±0.00 N/A N/A N/A
ENST00000550782 1.403±0.00 2.041±0.00 3.837±0.00 N/A N/A N/A N/A N/A 2.616±0.00 N/A 1.113±0.00 N/A 2.298±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007B4 CIL_0007B4_0001 CGP 12:50953922-51028566

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000041 IEA transition metal ion transport
GO:0001666 IEP response to hypoxia
GO:0003032 IEP detection of oxygen
GO:0005215 IEA transporter activity
GO:0005375 IDA copper ion transmembrane transporter activity
GO:0005381 IEA iron ion transmembrane transporter activity
GO:0005384 IDA manganese ion transmembrane transporter activity
GO:0005385 IDA zinc ion transmembrane transporter activity
GO:0005506 IEA iron ion binding
GO:0005507 IEA copper ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005764 IDA lysosome
GO:0005765 IDA lysosomal membrane
GO:0005768 IEA endosome
GO:0005769 IDA early endosome
GO:0005770 IDA late endosome
GO:0005773 IMP vacuole
GO:0005802 IDA trans-Golgi network
GO:0005886 IMP plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0005903 IEA brush border
GO:0006778 IEA porphyrin-containing compound metabolic process
GO:0006779 IEA porphyrin-containing compound biosynthetic process
GO:0006783 IEA heme biosynthetic process
GO:0006810 IEA transport
GO:0006824 IDA cobalt ion transport
GO:0006825 IDA copper ion transport
GO:0006826 IEA iron ion transport
GO:0006828 IDA manganese ion transport
GO:0006878 IEA cellular copper ion homeostasis
GO:0006879 TAS cellular iron ion homeostasis
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007611 IEA learning or memory
GO:0008270 IEA zinc ion binding
GO:0009986 IDA cell surface
GO:0010039 IEP response to iron ion
GO:0010042 IEA response to manganese ion
GO:0010288 IEA response to lead ion
GO:0012505 IEA endomembrane system
GO:0015078 IEA hydrogen ion transmembrane transporter activity
GO:0015086 IDA cadmium ion transmembrane transporter activity
GO:0015087 IDA cobalt ion transmembrane transporter activity
GO:0015093 IDA ferrous iron transmembrane transporter activity
GO:0015094 IDA lead ion transmembrane transporter activity
GO:0015099 IDA nickel cation transmembrane transporter activity
GO:0015100 IDA vanadium ion transmembrane transporter activity
GO:0015295 IDA solute:proton symporter activity
GO:0015675 IDA nickel cation transport
GO:0015676 IDA vanadium ion transport
GO:0015684 IDA ferrous iron transport
GO:0015692 IDA lead ion transport
GO:0015992 IEA proton transport
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016151 IEA nickel cation binding
GO:0016324 IDA apical plasma membrane
GO:0022890 IGI inorganic cation transmembrane transporter activity
GO:0030145 IEA manganese ion binding
GO:0031410 IDA cytoplasmic vesicle
GO:0031902 IDA late endosome membrane
GO:0034599 IDA cellular response to oxidative stress
GO:0035444 IDA nickel cation transmembrane transport
GO:0045177 IDA apical part of cell
GO:0045178 IDA basal part of cell
GO:0046686 IEA response to cadmium ion
GO:0046870 IEA cadmium ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048813 IEA dendrite morphogenesis
GO:0048821 IEA erythrocyte development
GO:0050897 IEA cobalt ion binding
GO:0055037 IDA recycling endosome
GO:0055085 TAS transmembrane transport
GO:0060586 IMP multicellular organismal iron ion homeostasis
GO:0070574 IDA cadmium ion transmembrane transport
GO:0070627 IDA ferrous iron import
GO:0070826 IDA paraferritin complex
GO:0071281 IEA cellular response to iron ion
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071421 IDA manganese ion transmembrane transport
GO:0071456 IEA cellular response to hypoxia
GO:0071577 IDA zinc ion transmembrane transport
GO:0098655 IGI cation transmembrane transport
GO:1902600 IEA hydrogen ion transmembrane transport
GO:1902861 IEA copper ion import into cell

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024295 slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 protein_coding Danio_rerio
ENSMUSG00000023030 Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 protein_coding Mus_musculus

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