C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 3-hydroxy-3-methylglutaryl-CoA reductase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113161 HMGCR 9606 + 5:75336329-75362104 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000287936 HMGCR-001 75337168-75362104 protein_coding
  ENST00000343975 HMGCR-004 75337232-75361423 protein_coding
  ENST00000442032 HMGCR-010 75339532-75342660 protein_coding
  ENST00000504466 HMGCR-007 75349863-75351610 retained_intron
  ENST00000507942 HMGCR-009 75338133-75344300 protein_coding
  ENST00000508070 HMGCR-011 75355180-75356449 retained_intron
  ENST00000509085 HMGCR-005 75358682-75360482 protein_coding
  ENST00000509431 HMGCR-008 75337246-75344030 retained_intron
  ENST00000511206 HMGCR-002 75336329-75360758 protein_coding
  ENST00000511986 HMGCR-006 75358690-75360481 protein_coding
  ENST00000512053 HMGCR-014 75359917-75360529 retained_intron
  ENST00000514315 HMGCR-013 75358730-75359761 retained_intron
  ENST00000515776 HMGCR-012 75354308-75355166 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000287936ENST00000343975ENST00000504466ENST00000509085ENST00000511206ENST00000511986
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000287936 1.236±0.00 1.956±0.00 N/A 3.418±0.32 1.937±0.41 1.859±0.00 0.972±0.00 4.034±0.67 6.139±0.00 4.297±2.11 0.111±0.00 16.438±1.85 5.014±1.05 6.850±2.18
ENST00000343975 0.523±0.00 1.251±0.00 1.384±0.00 5.716±1.45 1.213±0.05 7.578±0.00 0.637±0.18 1.594±0.00 3.183±1.14 2.048±0.30 0.423±0.00 1.994±0.61 1.767±0.29 2.263±0.00
ENST00000504466 N/A N/A N/A N/A N/A 7.667±0.00 N/A N/A N/A N/A N/A N/A 5.995±0.00 8.856±0.00
ENST00000509085 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.685±0.00
ENST00000511206 N/A N/A 1.087±0.00 2.144±0.00 N/A 1.898±0.00 0.303±0.00 N/A 0.723±0.00 2.027±0.00 0.343±0.00 3.373±0.00 N/A N/A
ENST00000511986 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.799±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004420 IEA hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515 IPI protein binding
GO:0005778 IDA peroxisomal membrane
GO:0005783 IDA endoplasmic reticulum
GO:0005789 TAS:IEA endoplasmic reticulum membrane
GO:0006695 TAS cholesterol biosynthetic process
GO:0006743 IEA ubiquinone metabolic process
GO:0007568 IEA aging
GO:0007584 IEA response to nutrient
GO:0008158 IEA hedgehog receptor activity
GO:0008284 IEA positive regulation of cell proliferation
GO:0008299 IEA isoprenoid biosynthetic process
GO:0008542 IEA visual learning
GO:0010664 IEA negative regulation of striated muscle cell apoptotic process
GO:0010666 IEA positive regulation of cardiac muscle cell apoptotic process
GO:0015936 IEA coenzyme A metabolic process
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016616 IEA oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0032874 IEA positive regulation of stress-activated MAPK cascade
GO:0042282 IDA hydroxymethylglutaryl-CoA reductase activity
GO:0042803 IEA protein homodimerization activity
GO:0043066 IEA negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043407 IEA negative regulation of MAP kinase activity
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045445 IEA myoblast differentiation
GO:0045471 IEA response to ethanol
GO:0045908 IEA negative regulation of vasodilation
GO:0048643 IEA positive regulation of skeletal muscle tissue development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050661 IEA NADP binding
GO:0050662 IEA:IDA coenzyme binding
GO:0051262 IDA protein tetramerization
GO:0055114 IEA oxidation-reduction process
GO:0061045 IEA negative regulation of wound healing
GO:0061179 IEA negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070402 IDA NADPH binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052734 hmgcra 3-hydroxy-3-methylglutaryl-Coenzyme A reductase a protein_coding Danio_rerio
ENSDARG00000059301 hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b protein_coding Danio_rerio
ENSMUSG00000021670 Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase protein_coding Mus_musculus

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